Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes.

By I. Kehat, Dorit Kenyagin-Karsenti, Mirit Snir, H. Segev, M. Amit, A. Gepstein, E. Livne, O. Binah, J. Itskovitz‐Eldor, L. Gepstein. Journal of Clinical Investigation, 2001

1,827 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/84d07718fa5452e3899d6070d17b4bbdcb87bd61

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In Biomedical Engineering

1. G. Keller
2. Kenneth R. Boheler
3. A. Bishop
4. A. Wobus
5. K. Hochedlinger
6. H. Rippon

In Cellular and Molecular Neuroscience

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In Molecular Biology

1. G. Keller
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8. Kenneth R. Boheler

Citations in the corpus

• Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. (2005, background): “Human ES cells have demonstrated the potential to differentiate into CMCs in vitro (50), but recent human ES cell transplantation into murine ischemic hearts has been shown to result in teratoma formation.”
• Regenerating the heart (2005, background): “As with their mouse counterparts, human ES cell–derived cardiomyocytes show the expected molecular, structural, electrophysiologic and contractile properties of nascent embryonic myocardiu”
• Embryonic stem cells (2004, background): “…et al. 2003), strategies to select out the appropriate cell type from the differentiated population (Muller et al. 2000), and cardiomyocytes are now being generated from human ES cells based on protocols optimized for murine ES cells (Kehat et al. 2001; He et al. 2003; Mummery et al. 2003).”
• Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming (2012, neutral): “The EB methodology initially involved suspending hPSC colonies in media containing 20% FBS to form spherical aggregates (Kehat et al., 2001).”
• Unchain my heart: the scientific foundations of cardiac repair. (2005, background): “The formation of functional cardiomyocytes by mouse and human embryonic stem cells is proven according to many criteria (83, 84).”
• Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts (2006, background): “Although recent progress in stem cell research has opened new perspectives for cell sourcing (for example, from embryoni”
• Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, result): “As observed with the mouse system, the cells differentiate over time in culture, following a maturation process similar to that reported in vivo (Kehat et al. 2001; Nir et al. 2003; Snir et al. 2003).”
• Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “The cardiac-specific gene expression pattern, electrophysiological properties, and chronotropic responses to adrenergic and muscarinic agonists are also typical of cardiomyocytes (188, 239, 240, 402).”
• Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts (2007, background): “hES cells are an attractive population for cardiac repair because they can be isolated and maintained by well-established protocols, can be greatly expanded in culture and can be differentiated into definitive cardiomyocyte”