Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts

By M. Laflamme, Kent Chen, A. Naumova, V. Muskheli, James A. Fugate, Sarah K. Dupras, H. Reinecke, Chunhui Xu, M. Hassanipour, Shailaja Police and 9 more. Nature Biotechnology, 2007

2,272 citations recorded by the source corpus.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/9cbdcec5d11ac30828ee3d7ce583dd8251ab19b8

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Citations in the corpus

Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. (2008, background): “In studies of human ESC-derived cardiomyocytes in the infarcted heart, a prosurvival cocktail that targeted multiple points in the death signaling network succeeded in generating physiologically significant graft sizes, whereas individual interventions were without benefit (Laflamme et al., 2007).”
Proangiogenic scaffolds as functional templates for cardiac tissue engineering (2010, methodology): “were obtained using protocols developed in our laboratories (40) (SI Mate-”
Improving Viability of Stem Cells During Syringe Needle Flow Through the Design of Hydrogel Cell Carriers (2011, positive): “Certain hydrogels may also strategically deliver anti-apoptotic or pro-stimulatory factors.(1) In contrast, here we focus on the role of hydrogels during the injection procedure (as opposed to post-delivery), when the presence of a viscoelastic material may serve to protect cells from the damaging m”
Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction (2015, background): “failure, however, this also has been reported to enhance arrhythmogenic response.(12,13) In spite of their impressive cardiac repair ability, teratoma formation has been observed(14,15) after transplantation of an unpurified ESC-derived cardiomyocyte population.”
Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development (2015, methodology): “Standard cardiomyocyte directed differentiation using a monolayer platform was performed with a modified protocol based on previous reports [47 – 49].”
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. (2007, background): “We next examined directed cardiac differentiation of human iPS cells with the recently reported protocol, which utilizes activin A and bone morphogenetic protein (BMP) 4 (Laflamme et al., 2007).”
Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors (2010, background): “Embryonic stem cells possess clear cardiogenic potential, but efficiency of cardiac differentiation, risk of tumor formation, and issues of cellular rejection must be overcome (Ivey and Srivastava, 2006; Laflamme et al., 2007; Nussbaum et al., 2007; van Laake et al., 2008).”
Structural and Functional Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells (2013, positive): “PSCs were maintained and differentiated as previously described [5].”