Regenerating the heart

By M. Laflamme, Charles E. Murry. Nature Biotechnology, 2005

1,056 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/c7ace2b1379803082f4484bdfcec4af2c07db274

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Citations in the corpus

Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration (2016, methodology): “Cardiac regeneration”
Potential risks of bone marrow cell transplantation into infarcted hearts. (2007, methodology): “We here addressed these important questions by using (1) genetically labeled cells, (2) whole BM and different fractions of BM-derived cell populations, (3) careful characterization of the cell biologic properties of the MSCs and their in vitro differentiation potential, (4) different types of myoca”
Mammalian Heart Renewal by Preexisting Cardiomyocytes (2012, neutral): “Tissue autofluorescence can reduce the sensitivity and specificity of immunofluorescent methods of detecting cell cycle activity 5,13 , including as cell cycle markers or incorporation of halogenated nucleotide analogues.”
Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming (2012, neutral): “In cases of myocardial infarction, 1 billion cells would potentially need to be replaced (Laflamme and Murry, 2005), highlighting the need for high-throughput and reproducible methodologies for de novo cardiomyocyte production.”
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts (2007, background): “Both adult and embryonic stem cells are being studied in preclinical models, and at least four types of autologous cells (skeletal myoblasts, bone marrow mononuclear cells, mesenchymal stem cells and endothelial progenitor cells) are being tested in early-stage clinical trial”
Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease (2012, background): “Regeneration of an infarcted heart necessitates massive cell replenishment, possibly in the order of a billion cardiomyocytes, and functional integration together with supporting cell types (Laflamme and Murry, 2005).”
Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair (2007, background): “Observations spanning the twentieth century show that some cardiomyocytes in the adult heart undergo DNA synthesis and mitosi”