Unchain my heart: the scientific foundations of cardiac repair.

By Stefanie Dimmeler, A. Zeiher, M. Schneider. Journal of Clinical Investigation, 2005

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How researchers see this paper

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Regenerating the heart (2005, background): “Clinical trials involving bone marrow for myocardial repair have recently been reviewed in detai”
A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. (2006, neutral): “Experimental attempts to modify this deficiency are underway, including delivery of growth factors or bone marrow-derived cells that may promote neovascularization in a paracrine manner or become incorporated into vessels (reviewed in Dimmeler et al., 2005 ).”
Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. (2007, background): “CML is characterized by a unique chromosomal translocation, t(9;22), that results in a BCR/ABL fusion gene product.”
Engineering Complex Tissues (2006, positive): “The cell transplant model used in experimental and early clinical trials of cell-based therapy for myocardial tissue repair uses cells injected at a specific tissue site, in the hope that these cells will differentiate and proliferate, and/or stimulate repair by functional tissue.(174) More recent a”
Hippo pathway effector Yap promotes cardiac regeneration (2013, background): “In addition to stem cell transplantation (2, 3), recent studies have suggested strategies for repairing the adult heart through reprogramming of nonmyocytes to a cardiac cell fate using cardiogenic genes and small molecules (4– 10).”