Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

By T. Bartosh, Joni H. Ylöstalo, Arezoo Mohammadipoor, N. Bazhanov, Katie Coble, K. Claypool, R. Lee, Hosoon Choi, D. Prockop. Proceedings of the National Academy of Sciences of the United States of America, 2010

924 citations recorded by the source corpus.

Subfields: Genetics, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/0a8e48a24542a7b86f39db892f93d268b401b752

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. C. Gregory
2. Jeffrey L Spees
3. J. Karp
4. R. Lee

In Surgery

1. C. Gregory
2. Jeffrey L Spees
3. J. Karp
4. R. Lee

Citations in the corpus

• Opportunities and Challenges for use of Tumor Spheroids as Models to Test Drug Delivery and Efficacy (2012, neutral): “Compared with conventional culture, spheroid cultures maintain key properties of stem cells, including gene expression profiles, colony-forming and/or tumorigenic activity, differentiation potential, cytokine secretion, and resistance to chemotherapy [23–36].”
• Mechanisms of mesenchymal stem/stromal cell function (2016, background): “tion is a common theme in many culture models [54, 55].”
• Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease (2012, background): “In a separate study, hMSC spheroids grown in suspension cultures were found to secrete 60-fold more TSG-6 protein than adherent monolayered hMSCs (Bartosh et al., 2010).”
• 3D bioactive composite scaffolds for bone tissue engineering (2017, background): “accelerate the growth of printed constructs towards clinically relevant, functional tissue [86,367,455,457,458].”
• Stem Cell Organoid Engineering (2016, neutral): “3D cell aggregate cultures of mesenchymal stem cells (MSCs) (Bartosh et al., 2010) or tumor cells (Vinci et al.”