Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation

By Catherine M. Kolf, Elizabeth Cho, Rocky S. Tuan. Arthritis Research & Therapy, 2007

932 citations recorded by the source corpus.

Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition we review recent research on the concept of stem cell niche, and its relevance to adult mesenchymal stem cells.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/e2fc6e295b1b8e1a15ab735e31bbca82308aae59

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. G. T. Huang
2. S. Shi
3. S. Gronthos
4. Rocky S. Tuan
5. A. Caplan

In Molecular Biology

1. S. Shi
2. G. T. Huang
3. S. Gronthos

Citations in the corpus

• Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine (2009, background): “The search for MSC-like cells in specific tissues has led to the discovery of a variety of stem cells in every organ and tissue in the body in the past decades (reviewed by Baksh et al., 2004; Porada et al., 2006; Kolf et al., 2007).”