Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium.

By L. Timmers, S. Lim, F. Arslan, J. Armstrong, I. Hoefer, P. Doevendans, J. Piek, R. El Oakley, A. Choo, C. Lee and 2 more. Stem Cell Research, 2008

613 citations recorded by the source corpus.

Subfields: Biomaterials, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/ec55197199362708d0a7ad61bbab97f9e4512a48

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Citations in the corpus

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. (2013, background): “Like others (Deuse et al., 2009; Matsuura et al., 2009; Rogers et al., 2011), we have demonstrated that culture medium conditioned by MSCs reduces I/R injury in a pig and mouse model (Timmers et al., 2007).”
Advances in therapeutic applications of extracellular vesicles (2019, result): “The therapeutic benefits were instead suggested to be imparted by the secretome of MSCs, a hypothesis that was strengthened by observations that MSC-CM (conditioned media) could achieve therapeutic efficacy similar to that realized by MSC administration in many paradigms (26, 27).”
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. (2010, background): “An intravenous bolus administration of MSC-CM just before reperfusion substantially reduced infarct size in both pig and mouse models of MI/R injury by ~60 and ~50%, respectively (Timmers et al., 2008).”
Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine (2017, background): “BMMSCs: Bone marrow-derived mesenchymal stem cells; ADSCs: Adipose-derived stem cells; DPSC: Dental pulp stem cells; WJMSCs: Umbilical cord Wharton's Jelly mesenchymal stem cells; hUCESCs: Human uterine cervical stem cells; UCPVCs: Umbilical cord perivascular cells; PDLSCs: Periodontal ligament stem”
Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs (2009, background): “hESC-derived MSCs was cardioprotective in both pig and animal models of myocardial ischemia and reperfusion injury (26).”
Exosomes Derived from Mesenchymal Stem Cells (2014, methodology): “In a porcine model of myocardial ischemia and reperfusion (MI/R) injury, intravenous and intracoronary MSC-CM treatment reduces the infarct size by approximately 50% when administered just prior to reperfusion [55].”