Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury.
By S. Gatti, S. Bruno, M. Deregibus, A. Sordi, V. Cantaluppi, C. Tetta, G. Camussi. Nephrology, Dialysis and Transplantation, 2011
797 citations recorded by the source corpus.
Subfields: Cancer Research, Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e99261b97248806063ccf65bb82a67ba7cf7a967
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Citations in the corpus
- Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model (2013, background): “Nevertheless, the detailed principles on the function of MSC-EVs need further investigations to be clarified, and the composition should be analyzed in the coming experiments to find out whether it is similar to that of EVs from other cell types [41, 42, 46].”
- Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression (2018, background): “It is increasingly evident that EVs play a major role in the regulation of physiological processes, such as tissue repair (4), stem cell maintenance (5), and coagulation (6).”
- Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties. (2015, positive): “3,4 7 Hence, EVs are emerging as disease biomarkers and nanotherapeutics.”
- Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases (2019, background): “[70] and Ju and et al [73], MSC-EV-based renoprotection was diminished by RNase pretreatment [74], confirming the hypothesis that beneficial effects of MSCs-EVs were mainly mediated by MSC-sourced mRNA.”
- Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications (2020, positive): “At the same time, exosomes can deliver a variety of bioactive substances and easy-to-deactivate or easily degradable ingredients (referring to therapeutic agents that have a short retention time in the body when administered alone) through multiple pathways and sites, and safely transfer them to tar”
- Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. (2012, background): “Subsequently, microvesicles from different sources including mesenchymal stem cells (MSCs) and liver stem cells were also found to confer therapeutic benefit in a range of different diseases; enhancing survival in acute (37,88) and chronic (89) kidney injuries and peripheral arterial disease (90) as”
- Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine (2018, background): “[25] showed that injection of MSC-EVs protected rats from AKI through reducing apoptosis and increasing tubular epithelial cell proliferation and subsequently improved renal function.”
- Mechanisms of mesenchymal stem/stromal cell function (2016, background): “Exosomes purified from MSCs have garnered tremendous interest in the field of regenerative medicine based on their ability to reduce apoptosis/necrosis in rodents after ischemic injury to the heart [158, 159], brain [160, 161], lung [162], liver [163], or kidney [164].”
- Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. (2015, background): “The same mechanism is thought to protect the kidney from I/R through the miRNA-dependent reprogramming of renal resident cells imparted by the delivery of microvesicles released by endothelial progenitor cells or MSCs (92, 93).”