Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.

By George A. Calin, Chang-Gong Liu, M. Ferracin, T. Hyslop, R. Spizzo, C. Sevignani, M. Fabbri, A. Cimmino, E. J. Lee, Sylwia E. Wojcik and 17 more. Cancer Cell, 2007

744 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8343234c3fe68ce13dd693944142d101521c4167

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Citations in the corpus

Non-coding RNAs in human disease (2011, background): “Surprisingly, 68% of UCRs (that is, 325 of them) are transcribed, constituting a new category of ncRNAs, the T-UCR”
Non‐coding RNAs: regulators of disease (2010, background): “It is not surprising, then, that the dysregulation of lncRNAs appears to be a primary feature of many complex human diseases, including leukaemia [175], colon cancer [176], prostate cancer [177], breast cancer [178], hepatocellular carcinoma [175,179], psoriasis [180], ischaemic heart disease [181,1”
The rise of regulatory RNA (2014, background): “However, it is clear that lncRNAs actually show a wide range of evolutionary conservation, from those that are ultraconserved 185 to those that are primate-specific 186–188 , which can be explained as the result of different structure-function constraints and lineage-specific adaptive radiation 189…”
Long intergenic non-coding RNAs – New links in cancer progression (2011, background): “Although lincRNAs may have an impact on various human diseases (10, 13, 14), the basis of their molecular mechanisms is still largely unknown.”
Non-coding RNAs in disease: from mechanisms to therapeutics (2023, neutral): “Plenty of lncRNAs are transcribed from genomic regions that are perfectly conserved between humans, mice and rats, termed ultra-conserved elements (UCEs) 122 .”
Long noncoding RNA in prostate, bladder, and kidney cancer. (2014, methodology): “Another key question that remains to be answered is what causes the strikingly specific expression of most lncRNAs in normal and cancerous tissues [8,11,72].”
The emergence of lncRNAs in cancer biology (2011, background): “Subsequently, numerous ultraconserved sequences were found to be transcriptionally active, defining a class of T-UCRs as ncRNAs (18).”
Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs (2012, background): “This includes breast cancer (53), colorectal cancer (81), prostate cancer (82), hepatocellular carcinoma (83–85), leukemia (86,87), melanoma (88) and possibly others (76,89).”
MicroRNAs — the micro steering wheel of tumour metastases (2009, background): “Other ncRNAs, such as non-coding ultraconserved genes (transcripts that arise from stretches of the genome with 100% conservation between human, rat and mouse genomes”