Non-coding RNAs in human disease

By Manel Esteller. Nature reviews genetics, 2011

4,652 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d86e2351a43c195ff6b4833d0452a6c552854133

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Zhuhong You
2. Chenggang Clarence Yan
3. Xu Zhang
4. Di Xie
5. Qi Zhao
6. Xing Chen
7. J. Tyler
8. Yin-yuan Mo

In Molecular Biology

1. Zhuhong You
2. Julia Salzman
3. Chenggang Clarence Yan
4. Xu Zhang
5. Di Xie
6. Qi Zhao
7. Xing Chen
8. J. Tyler

Citations in the corpus

• LNCcation: lncRNA localization and function (2021, background): “…numerous cellular processes, including the cell cycle (Kitagawa et al., 2013), differentiation (Ballarino et al., 2016; Brazão et al., 2016; Delás et al., 2017), and metabolism (Sirey et al., 2019; Sun and Wong, 2016), as well as in disease (Esteller, 2011; Wang et al., 2013; Yuan et al., 2014).”
• LncRNA-mediated regulation of cell signaling in cancer (2017, background): “…were initially considered as transcriptional noises (Gibb et al 2011), however, it has become increasingly apparent that they may play a critical role in diverse cellular processes from normal development to disease processes (Esteller 2011, Fatica and Bozzoni 2014, Wang et al 2013a, Wilusz 2016).”
• Long non-coding RNAs and complex diseases: from experimental results to computational models (2016, background): “Recently, increasing evidences have revealed that ncRNAs play a critical role in multiple fundamental and important biological processes [10].”
• Circular RNAs are abundant, conserved, and associated with ALU repeats. (2013, background): “Though the bulk of these noncoding RNAs consist of the rRNA and tRNA apparatus required for translation, it has been increasingly appreciated that noncoding products comprise a diverse set of species relevant in core biological processes and disease (Esteller 2011).”
• Epigenetics and aging (2016, background): “Disruption of ncRNA function has been implicated in numerous disease conditions, such as cancer, neurodegenerative disorders, cardiovascular disorders, and aging (172, 173).”
• microRNA as Biomarkers and Diagnostics (2016, background): “Identification of tumor specific genetic alterations in the miRNA processing machinery, such as in the genes encoding TARBP2, AGO2, Dicer and Exportin-5 (XPO5) provide strong evidence of these pathways being relevant in cellular transformation process (Esteller, 2011).”
• miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions (2013, background): “…miRNAs bind to complementary sequences in the 3 0 un-translated regions of their target mRNAs and induce mRNA degradation or translation repression (4). miRNAs play important roles in causing many diseases including various types of cancer, cardiovascular diseases and neurological disorders (5–8).”