The emergence of lncRNAs in cancer biology

By John R. Prensner, Arul M. Chinnaiyan. Cancer Discovery, 2011

1,751 citations recorded by the source corpus.

The discovery of numerous non-coding RNA (ncRNA) transcripts in species from yeast to mammals has dramatically altered our understanding of cell biology, especially disease biology such as cancer. In humans, the identification of abundant long ncRNA (lncRNAs) >200 bp in length has catalyzed their characterization as critical components of cancer biology. Recently, roles for lncRNAs as drivers of tumor suppressive and oncogenic functions have appeared in prevalent cancer types, such as breast and prostate cancer. In this review, we will highlight the emerging impact of ncRNAs in cancer research, with a particular focus on the mechanisms and functions of lncRNAs.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/26ae715ca80c4057a9e1ddce311b45ce5e2de835

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Citations in the corpus

TSGene 2.0: an updated literature-based knowledgebase for tumor suppressor genes (2015, background): “Accumulating lines of evidence have shown that non-protein coding RNAs, such as miRNAs (9–11) and lncRNAs (12), can act as TSGs to initiate and promote cancer development.”
Long non-coding RNAs: a new frontier in the study of human diseases. (2013, neutral): “21 Functions as a transcriptional repressor [50,51]”
The Landscape of Long Noncoding RNAs in the Human Transcriptome (2015, neutral): “MiTranscriptome expression data Transcripts (381,821) Samples (6,475)”
Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19 (2018, background): “Further data showed that H19 could regulate many biological processes as an endogenous sponge for miRNAs.”
Comprehensive Genomic Characterization of Long Non-Coding RNAs across Human Cancers (2015, background): “…from enhancer regions or their neighboring loci (Batista and Chang, 2013; Guttman and Rinn, 2012; Karreth and Pandolfi, 2013; Lee, 2012; Mattick and Rinn, 2015; Mercer et al., 2009; Morris and Mattick, 2014; Ørom and Shiekhattar, 2013; Prensner and Chinnaiyan, 2011; Ulitsky and Bartel, 2013).”
FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome (2017, background): “From the pioneer discovery of the Xist lncRNA involved in X chromosome inactivation in placental females (8) to the more recent links between lncRNAs and cancers (9,10), lncRNAs have emerged as key actors of the cell machinery with diverse modes of action such”
TANRIC: An interactive open platform to explore the function of lncRNAs in cancer (2015, positive): “Among noncoding RNAs, long noncoding RNAs (lncRNAs), typically >200 bp, have increasingly been recognized as playing essential roles in tumor biology, representing a new focus in cancer research (2-4).”
Revealing protein–lncRNA interaction (2015, neutral): “Several other examples can be found in recent reviews [23–27].”