Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs
By Victoria A. Moran, Ranjan J. Perera, A. Khalil. Nucleic Acids Research, 2012
628 citations recorded by the source corpus.
The recent discovery that the human and other mammalian genomes produce thousands of long non-coding RNAs (lncRNAs) raises many fascinating questions. These mRNA-like molecules, which lack significant protein-coding capacity, have been implicated in a wide range of biological functions through diverse and as yet poorly understood molecular mechanisms. Despite some recent insights into how lncRNAs function in such diverse cellular processes as regulation of gene expression and assembly of cellular structures, by and large, the key questions regarding lncRNA mechanisms remain to be answered. In this review, we discuss recent advances in understanding the biology of lncRNAs and propose avenues of investigation that may lead to fundamental new insights into their functions and mechanisms of action. Finally, as numerous lncRNAs are dysregulated in human diseases and disorders, we also discuss potential roles for these molecules in human health.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/34e009b7899f41731a058be0b9f1d805a24fca1d
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Citations in the corpus
- Long Non-coding RNAs in the Cytoplasm (2016, background): “This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).”
- Histone Deacetylase Inhibitors as Anticancer Drugs (2017, background): “They also have epigenetic effects and are precursors of miRNAs [93].”
- Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer (2016, background): “Many lncRNAs have been characterized and several models of action have been proposed, such as functioning as signal, decoy, scaffold, guide, enhancer RNAs, and short peptides [19,20], as mentioned below.”
- Long non-coding RNAs and complex diseases: from experimental results to computational models (2016, background): “Furthermore, lncRNAs are confirmed to play critical roles in multiple biological processes [3, 18, 77–80].”
- Long non-coding RNAs: a new frontier in the study of human diseases. (2013, background): “Therefore, aberrant lncRNA expression can cause various human diseases and disorders (Table 1) [14].”