MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis.

By W. Tsai, Sheng-Da Hsu, Chu-Sui Hsu, T. Lai, Shu-Jen Chen, R. Shen, Yi Huang, Hua-Chien Chen, C. Lee, T. Tsai and 6 more. Journal of Clinical Investigation, 2012

808 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/605223d88f048af4b2c6b81723af925c56ea28c1

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Citations in the corpus

microRNAs in cancer (2013, background): “Several strains of mice lacking or overexpressing cancer-associated miRNAs have been developed and characterized, including the germ-line transgenic or knockout mice of miR155 (39), miR-17/92 and its paralogs (60–62), miR-21 (40), miR-221 (63), the miR-15/16-1 cluster (64), miR-122 (65, 66), and miR”
miR-122--a key factor and therapeutic target in liver disease. (2015, background): “The proof-of-concept that miR-122 has an anti-tumour function in the liver was again provided using miR-122 KO mice [38,39].”
Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma (2015, background): “progression [10] and is closely related to poor prognosis and metastasis of HCC [11].”
An overview of microRNAs (2015, background): “Targeted deletion of miR-122 in mouse models leads to reduced serum cholesterol and triglyceride levels[180, 181].”
Development of microRNA therapeutics is coming of age (2014, neutral): “However, two recent studies reported that chronic loss of miR-122 function in Mir122 germline knockout and liver-specific knockout mice, respectively, resulted in increased incidence of steatohepatitis and hepatocellular carcinoma with age (Hsu et al , 2012; Tsai et al , 2012).”
Metazoan MicroRNAs (2018, background): “miR-122 (1) miR-122 Development of fatty liver, hepatitis, fibrosis, and hepatocellular carcinoma (Hsu et al., 2012; Tsai et al., 2012); smaller hepatocytes with substantially fewer polyploid cells (Hsu et al.”