MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.

By T. Papagiannakopoulos, Alice Shapiro, Kenneth S. Kosik. Cancer Research, 2008

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MicroRNAs in development and disease. (2011, background): “In agreement, knockdown of miR-21 results in activation of these pathways, cell cycle arrest, and apoptosis, plausibly through its validated targets, which include heterogeneous nuclear ribonucleoprotein K (HNRK), p53-related TAp63 (469), and PDCD4 (FIGURE 6), in glioblastoma cell lines (98).”
miR-21: a small multi-faceted RNA (2008, background): “also suggest the regulation of the TGF- pathway by miR-21 [97].”
Genetics of adult glioma. (2012, background): “miR-21 is upregulated in gliomas, as inhibition of miR-21 leads to apoptosis, limits invasion, represses cell growth, and is associated with chemosensitization (59,60).”