NIX is required for programmed mitochondrial clearance during reticulocyte maturation

By R. L. Schweers, Ji Zhang, Mindy S. Randall, Melanie R. Loyd, Weimin Li, F. Dorsey, M. Kundu, J. Opferman, J. Cleveland, Jeffery L. Miller and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2007

902 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/80196820a86e597fb7825022b9e372a9fbf198b6

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In Cell Biology

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Citations in the corpus

• The pathways of mitophagy for quality control and clearance of mitochondria (2012, background): “In fact, Nix / mouse retain mitochondria in their erythrocytes and develop anemia due to decreased survival of those cells.12 Nix is required specifically for elimination of reticulocyte mitochondria, but not other organelles that are lost during maturation such as ribosomes and the nucleus.12,47 Ni”
• ROLE OF BNIP3 AND NIX IN CELL DEATH, AUTOPHAGY, AND MITOPHAGY (2009, positive): “A recent study provides evidence for a third potential mechanism of BNIP3- or NIX-induced cell death (Figure 2, right panel).38 BAX or BAK, and BCL2, have opposing effects on cell death, mediated at least in part through their effects on endoplasmic reticulum/sarcoplasmic reticulum (ER/SR) calcium s”
• Mitochondrial dynamics and mitochondrial quality control (2014, background): “The entry of mitochondria into autophagosomes for degradation was blocked in NIX-deficient mice, which led to life-span reduction of red blood cells and development of anemia [75,76].”
• The LIR motif – crucial for selective autophagy (2013, background): “During erythroid cell maturation, Nix mediates the complete removal of mitochondria (Schweers et al., 2007; Sandoval et al., 2008).”
• Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation (2011, background): “Recent research shows that the autophagy machinery can target specific substrates for degradation depending on the cell’s needs in specific contexts such as mitochondrial stress (27, 28).”
• Molecular mechanisms and physiological functions of mitophagy (2021, positive): “Mitochondrial elimination in response to developmental cues is crucial for maturation of cells and tissues. with these observations, loss of NIX in mice causes defects in mitochondrial clearance and anemia (Schweers et al , 2007; Sandoval et al , 2008).”
• Autophagy: assays and artifacts (2010, background): “Mitophagy is an integral part of reticulocyte maturation and defects in autophagy can lead to anaemia [27-29].”