Autophagy: assays and artifacts

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Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “The possibilities of postmortem autolysis and fixation artifacts must always be taken into consideration when interpreting changes attributed to autophagy.(813) Analyses of these types of samples require not only special antigen retrieval techniques, but also histopathological experience to interpre”
Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity (2012, background): “autophagy induction can both lead to autophagosome accumulation [23], and the possibility of autophagy blockade”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “always be taken into consideration when interpreting changes attributed to autophagy.(1343) Analyses of these types of samples”
Autophagy: cellular and molecular mechanisms (2010, background): “The synthesis and processing of LC3 is increased during autophagy, making it a key readout of levels of autophagy in cells [35].”
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein (2017, methodology): “Comparison of cells treated with and without bafilomycin A1 is a common method to monitor the rate of autophagosome formation within the cell independent of later steps (Barth et al., 2010).”