Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

By Ricky T. Tong, Y. Boucher, S. Kozin, F. Winkler, D. Hicklin, Rakesh K. Jain. Cancer Research, 2004

1,208 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bb1f761272aa99256a2f6cbc022b180e0f1c4610

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Citations in the corpus

Therapeutic targeting of the tumor microenvironment. (2005, positive): “The administration of VEGFR2-blocking antibodies, PDGF antago nists, and TGFβ inhibitors, among others, effectively reduces IFP, resulting in enhanced drug uptake (Lammerts et al., 2002; Pietras et al., 2002; Tong et al., 2004 ), as exemplified by the combinatorial efficacy of chemotherapy and PDG”
Tumor Targeting via EPR: Strategies to Enhance Patient Responses (2018, background): “Decreasing the IFP and/or solid stress can decompress blood and lymphatic vessels, and it may help to increase perfusion and nanomedicine accumulation [41].”
The microenvironmental landscape of brain tumors (2017, background): “In the brain, early studies demonstrated that microglia are the predominant APCs, and that DCs play a less-prevalent role (Hart and Fabre, 1981; Hickey and Kimura, 1988; Lowe et al., 1989; Ulvestad et al., 1994).”
Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions (2014, neutral): “been shown to result in either decreased or increased pericyte coverage, dependent on the study [130–133].”
Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize (2007, background): “2) [Tong et al., 2004; Willett et al., 2004].”
ANTIANGIOGENESIS STRATEGIES REVISITED: FROM STARVING TUMORS TO ALLEVIATING HYPOXIA (2014, positive): “A variety of preclinical studies using direct and indirect AA agents supported the normalization hypothesis (Izumi et al., 2002; Jain et al., 1998; Tong et al., 2004; Winkler et al., 2004; Yuan et al., 1996).”
Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems. (2006, background): “It was also suggested that the interstitial fluid pressure decreases in subcutaneously implanted U87 (glioblastoma) tumor in nude mice [154].”
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. (2007, background): “mammary carcinoma MCaIV transplanted in mice (26).”
Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. (2013, background): “Blockading VEGF in tumors causes a reduction in the size and diameter of blood vessels with improved blood perfusion, leading to increased delivery of small molecule drugs [83, 84].”
Drug penetration in solid tumours (2006, background): “, and changes in the above parameters have been quantified in response to various treatment”