VEGF in Signaling and Disease: Beyond Discovery and Development

By R. Apte, Daniel Chen, N. Ferrara. Cell, 2019

2,318 citations recorded by the source corpus.

The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our understanding of vasculogenesis and angiogenesis during development and physiological homeostasis. Over a short span of two decades, our understanding of the molecular mechanisms by which VEGF coordinates neurovascular homeostasis has become more sophisticated. The central role of VEGF in the pathogenesis of diverse cancers and blinding eye diseases has also become evident. Elucidation of the molecular regulation of VEGF and the transformative development of multiple therapeutic pathways targeting VEGF directly or indirectly is a powerful case study of how fundamental research can guide innovation and translation. It is also an elegant example of how agnostic discovery and can transform our understanding of human disease. This review will highlight critical nodal points in VEGF biology including recent developments in immunotherapy for cancer and multi-target approaches in neovascular eye disease.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/66e7ffcc31101a15e79c8a1fa37259c8154cde64

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Citations in the corpus

• Kidney fibrosis: from mechanisms to therapeutic medicines (2023, background): “However, VEGF is also a key antitumor drug target and the restoration of VEGF might pose a risk.(141) Therefore, other mechanisms regulating vascular rarefaction need to be discovered.”
• SARS-CoV-2 infection: The role of cytokines in COVID-19 disease (2020, neutral): “The pathogenic effects of this factor are related to its action on vascular permeability and neoangiogenesis [189,190].”