Mincle is an ITAM-coupled activating receptor that senses damaged cells

By S. Yamasaki, E. Ishikawa, Machie Sakuma, H. Hara, K. Ogata, T. Saito. Nature Immunology, 2008

705 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7edc4dd4f3c66a2c128692aec3478a9a8a7b0934

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Citations in the corpus

The SYK tyrosine kinase: a crucial player in diverse biological functions (2010, background): “CLEC4E, an FcRγ-associated fungal and mycobacterial PRR (see above), can sense necrotic cells after prolonged culture in vitro”
The sterile inflammatory response (2010, neutral): “In addition, a few intracellular molecules have also been found to have intrinsic proinflammatory activity including HMGB1 (39), SAP130 (40), IL-1α (37), IL-33 (41), DNA (42, 43), S100 proteins (44), heat shock proteins (45, 46) and others (47).”
Signalling through C-type lectin receptors: shaping immune responses (2009, background): “In macrophages, recognition of dead cells by mincle through the endogenous ligand sAP130 (sIN3A-associated protein, 130 kDa) mediates CXC-chemokine ligand 2 (CXCL2) and TNF production in a syK-and CARD9-dependent manner, which induces neutrophils to migrate into damaged tissues 12 .”
Pattern recognition receptors and inflammation. (2010, background): “In addition, MINCLE is responsible for the detection of an endogenous protein, spliceosome-associated protein 130 (SAP130), which is a component of U2 snRNP from necrotic host cells (Yamasaki et al., 2008).”
Cellular and molecular mechanisms of skin wound healing (2024, neutral): “The early release of DAMPs after wounding promotes the activation of tissue-resident macrophages to the wound site 103 .”
Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “Mincle is a multifunctional receptor recognizing Malassezia fungi [208], mycobacterial structures [203,209] and cytoplasmic danger signals (such as SAP130) [210].”
Phagocyte partnership during the onset and resolution of inflammation (2010, background): “Recently, CLEC4E (also known as MINCLE), a transmembrane C-type lectin receptor (CLR), was shown to be involved in initiating the early inflammatory response after necrotic cell deat”
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle (2009, background): “We have previously reported that Mincle transduces signal through the FcR–CARD9 signaling axis (Yamasaki et al., 2008).”
Sterile inflammation: sensing and reacting to damage (2010, background): “Although their primary importance is in host defence against pathogens, CLRs can sense necrotic cell deat”
Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “Recent work [140, 141] demonstrated that inhibition of MINCLE interrupts the release of proinflammatory cytokines by macrophages and also blocks neutrophil recruitment.”