Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail

By Junichi Ikenouchi, M. Matsuda, M. Furuse, S. Tsukita. Journal of Cell Science, 2003

700 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/7d0ecbce301339b44773532ece75b407439e81ed

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Jing Yang
2. K. Yeung
3. M. Bronner‐Fraser
4. M. Nieto
5. Yibin Kang

In Molecular Biology

1. M. Nieto
2. A. Cano
3. Jing Yang
4. G. Moreno-Bueno
5. K. Yeung
6. Yibin Kang
7. F. Portillo
8. R. Weinberg

In Neurology

1. M. Furuse
2. S. Tsukita
3. J. Turner
4. Takuya Suzuki
5. E. Dejana
6. Carola Förster
7. R. Lynch
8. E. Schneeberger

Citations in the corpus

• The Snail genes as inducers of cell movement and survival: implications in development and cancer (2005, background): “4 summarises those that are involved in processes in which Snail genes: repress epithelial markers (Cano et al., 2000; Batlle et al., 2000; Guaita et al., 2002; Ikenouchi et al., 2003; Tripathi et al., 2005a); upregulate mesenchymal markers (Cano et al.”
• Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells (2005, methodology): “Recently, Snail, a transcription repressor, was shown to play a central role in epithelial–mesenchymal transition (Nieto, 2002).”
• Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. (2009, positive): “Snail transcription factors bind to conserved E-box sequences within the promoters of their target genes, such as E-cadherin (38), as well as the genes encoding claudin-3, claudin-4, claudin-7, and occludin (41).”
• Transcriptional regulation of cell polarity in EMT and cancer (2008, background): “Apart from E-cadherin, other epithelial genes initially downregulated by Snail and ZEB factors are components of the tight junctions, including occludin and several members of the claudin family (Ikenouchi et al., 2003; Ohkubo and Ozawa, 2004; De Craene et al., 2005b; Vandewalle et al., 2005; Martı́”
• Epithelial-mesenchymal plasticity in cancer progression and metastasis (2019, background): “SNAI1 also has well-established function in repressing the expression of genes regulating tight junction formation and apical–basal polarity (Ikenouchi et al., 2003; Whiteman et al., 2008).”
• Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression (2010, background): “For example, Snail and Slug regulate tight junction stability [28], gap junctional protein expression [107], desmosome disassembly [34] and protease expression [108].”
• The tight junction: a multifunctional complex. (2004, neutral): “When Snail was overexpressed in epithelial cells, there was complete repression of occludin, claudin-3, -4, and -7, and E-cadherin expression at both mRNA and protein levels, and this was accompanied by the disruption of both TJs and adherens junctions with subsequent induction of EMT (72).”
• Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. (2006, background): “These multiple zinc finger–containing proteins inhibit expression of genes with conserved E-boxes in their promoter regions, including E-cadherin (27, 28), tight junction proteins such as occludin (29) and claudin (30), as well as important regulators of tight junction assembly such as Na,K-ATPase h”
• Epithelial–mesenchymal transition in tumor metastasis (2016, background): “Members of the SNAIL and ZEB families have also been shown to downregulate tight junction proteins including occludin, claudins, ZO-1, and connexins JAM1/A (Bax et al., 2011; Ikenouchi et al., 2003; Mart ınez-Estrada et al., 2006; Ohkubo and Ozawa, 2004; Vandewalle et al., 2005).”
• Tight junctions and cell polarity. (2006, background): “Snail decreases claudin expression, resulting in an increase in tight junction paracellular permeability and disruption of barrier function (Ikenouchi et al. 2003).”