Epithelial-mesenchymal plasticity in cancer progression and metastasis
By Wei Dang Lu, Yibin Kang. Developmental Cell, 2019
882 citations recorded by the source corpus.
Epithelial to mesenchymal transition (EMT) and its reversed process, mesenchymal to epithelial transition (MET) are fundamental processes in embryonic development and tissue repair, but confers malignant properties to carcinoma cells, including invasive behavior, cancer stem cell activity, and greater resistance to chemotherapy and immunotherapy. Understanding the molecular and cellular basis of EMT provides fundamental insights into the etiology of cancer and may, in the long run, lead to new therapeutic strategies. Here, we discuss the regulatory mechanisms and pathological roles of epithelial-mesenchymal plasticity, with a focus on recent insights into the complexity and dynamics of this phenomenon in cancer.
Subfields: Oncology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/3dadb612daa094738f5ff218198fd22498023da8
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In Oncology
Citations in the corpus
- The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “During transformation, the expression or function of epithelial genes such as E-cadherin-specific cytokeratin and zone of occlusion 1 (ZO-1) is lost, whereas the expression of genes defining the mesenchymal phenotype (such as vimentin, fibronectin, N-cadherin, β1 and β3 integrins) is enhanced [18, 3”
- Oxidative Stress in Cancer (2020, background): “In the latter case, oscillation between EMT and MET enables invading tumor cells to adapt to new environments (Dongre and Weinberg, 2019; Lu and Kang, 2019).”