Transcriptional regulation of cell polarity in EMT and cancer

By G. Moreno-Bueno, F. Portillo, A. Cano. Oncogene, 2008

612 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/217928a4eae9091ed236b0e5de370504599c9a23

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Citations in the corpus

Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications (2016, background): “It is important to highlight that oncogenic EMT is a transient process that may function in a paracrine fashion and is followed by MET once the tumor cells reach the metastatic site [21].”
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. (2009, positive): “Once epithelial cells become competent to respond to EMT-inducing signals, these signals can promote disruption of the intercellular adhesion complexes and loss of the characteristic apico-basal polarity of the epithelial cells (3–5).”
The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, background): “Another difference that emerges when comparing individual cell migration (EMT) and collective cell migration involves the regulation of cell polarity (Moreno-Bueno et al. 2008).”
Dynamic EMT: a multi‐tool for tumor progression (2021, positive): “Overexpression of SNAI1 , TWIST1 , and ZEB1 in breast cancer is sufficient to increase the CD44 + /CD24 lo stem cell pool, resulting in increased sphere forming capacity in vitro , as well as elevated tumorigenicity and metastasis in vivo (Mani et al , 2008; Morel et al , 2008).”
Epithelial-mesenchymal transitions in development and disease. (2009, background): “In epithelial cells, three protein complexes participate in establishing and maintaining apicobasal polarity (Par, Crumbs, and Scribble), and components of the three are regulated by EMT inducers (see review by Moreno-Bueno et al., 2008, and Table S1 for additional references).”
Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts (2013, background): “During EMT, epithelial cells lose cell-cell contacts, undergo cytoskeletal remodeling resulting in loss of polarity, and acquire amesenchymal morphology (Moreno-Bueno et al., 2008).”
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits (2009, background): “1 ; Table 1 ) have been demonstrated to be capable of orchestrating EMT programmes during embryonic development and in cance”