Tight junctions and cell polarity.

By Kunyoo Shin, V. Fogg, B. Margolis. Annual Review of Cell and Developmental Biology, 2006

786 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/be22c38a85683d2a6538cfb89ac94df78a59377a

How researchers see this paper

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In Cancer Research

1. Ankit Malhotra
2. Anindya Dutta
3. Yong Sun Lee
4. T. Sauka-Spengler
5. M. Bronner‐Fraser
6. Elaine Fuchs
7. C. Blanpain
8. V. Horsley

In Molecular Biology

1. C. Blanpain
2. Elaine Fuchs
3. V. Horsley
4. Ankit Malhotra
5. Anindya Dutta
6. Yong Sun Lee
7. T. Sauka-Spengler
8. M. Bronner‐Fraser

In Neurology

1. Elaine Fuchs
2. C. Blanpain
3. V. Horsley
4. C. Niessen

Citations in the corpus

• Tight junctions/adherens junctions: basic structure and function. (2007, background): “D culture conditions or animal models, will thus be necessary to rule out a function for tight junctions in apico-basolateral polarity and fence function (Shin and Margolis, 2006).”
• Mucins in cancer: function, prognosis and therapy (2009, background): “Tight junctions also prevent intramembrane diffusion of cell surface structures localized to the apical and basolateral domains of the polarized epithelial cel”
• Epithelial stem cells: turning over new leaves. (2007, positive): “In conjunction with integrins, intercellular junctions and associated components distinguish the apical, basal, and lateral surfaces of the cell, which are essential for establishing epithelial cell polarity (Shin et al., 2006).”
• From cells to organs: building polarized tissue (2008, background): “In vertebrates, tight junctions (TJs) are found at the apical-most portion of the lateral surfaces, where the TJs form barriers both between the apical and basolateral surfaces and between adjacent cells, limiting paracellular permeabilit”
• Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice (2007, positive): “Epithelial cell polarization relies on tight junctions, which connect tubule cells, provide paracellular barriers to ion and fl uid movement, and organize the membrane into apical and basolateral domains (Schneeberger and Lynch, 1992; Van Itallie and Anderson, 2004; Shin et al., 2006).”
• A gene regulatory network orchestrates neural crest formation (2008, background): “The dissolution of a tight junction involves down-regulation of structural proteins that constitute the junction's backbone, such as occludins, which are transmembrane proteins with possible roles in the regulation of signalling events at the junction, and claudins, which mediate calcium-independent”
• Butyrate Enhances Intestinal Epithelial Barrier Function via Up-Regulation of Tight Junction Protein Claudin-1 Transcription (2012, background): “In physiological conditions, TJ proteins completely surround the subapical region of epithelial cells and maintain structural integrity and normal functions of the intestinal epithelium [2, 3].”
• The Retinal Pigment Epithelium in Health and Disease (2010, background): “1) of RPE – a composite of tight, adherens and gap junctions - play a role in maintaining cell polarity by forming a physical barrier that prevents intramembranous diffusion of components between the apical and basolateral membrane domains [4, 5].”