Epithelial–mesenchymal transition in tumor metastasis

By K. Yeung, Jing Yang. Molecular Oncology, 2016

976 citations recorded by the source corpus.

The epithelial–mesenchymal transition (EMT) is a developmental program that enables stationary epithelial cells to gain the ability to migrate and invade as single cells. Tumor cells reactivate EMT to acquire molecular alterations that enable the partial loss of epithelial features and partial gain of a mesenchymal phenotype. Our understanding of the contribution of EMT to tumor invasion, migration, and metastatic outgrowth has evolved over the past decade. In this review, we provide a summary of both historic and recent studies on the role of EMT in the metastatic cascade from various experimental systems, including cancer cell lines, genetic mouse tumor models, and clinical human breast cancer tissues.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/0398b94cfa87215529b314a8558d57c79588dba6

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Citations in the corpus

• Macrophages in immunoregulation and therapeutics (2023, background): “All through the EMT process, tumor cells give up cell-to-cell intersections and apical-basal polarity because of E-cadherin suppression and secure an adaptable phenotype of mesenchymal cells.(314) Naturally, macrophages partake in the EMT procedure by discharging different dissolvable factors, for e”