HUMAN VIRAL ONCOGENESIS: A CANCER HALLMARKS ANALYSIS

By E. Mesri, M. Feitelson, K. Munger. Cell Host and Microbe, 2014

610 citations recorded by the source corpus.

Approximately twelve percent of all human cancers are caused by oncoviruses. Human viral oncogenesis is complex and only a small percentage of the infected individuals develop cancer and often many years to decades after initial infection. This reflects the multistep nature of viral oncogenesis, host genetic variability and the fact that viruses contribute to only a portion of the oncogenic events. In this review, the Hallmarks of Cancer framework of Hanahan & Weinberg (2000 and 2011) is used to dissect the viral, host and environmental co-factors that contribute to the biology of multistep oncogenesis mediated by established human oncoviruses. The viruses discussed include Epstein Barr Virus (EBV), high-risk Human Papillomaviruses (HPV16/18), Hepatitis B and C viruses (HBV, HCV respectively), Human T-cell lymphotropic virus-1 (HTLV-1) and Kaposi’s sarcoma herpesvirus (KSHV).

Subfields: Epidemiology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/d0fd1a802e3331d7eb693d2b2513c2166c126d26

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Citations in the corpus

• Exploration of prognosis-related microRNA and transcription factor co-regulatory networks across cancer types (2019, background): “Each cancer hallmark represents the biological capability for oncogenic progress that underlies [28] the tumour phenotype.”