Hypoxia-induced angiogenesis: good and evil.

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The roles of vascular endothelial growth factor in bone repair and regeneration (2016, background): “Hypoxia is considered a major driver of VEGF expression, especially in tumor tissues and bones [33, 34].”
Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves (2015, background): “pro-angiogenic factors such as VEGF (Krock et al., 2011; Pugh and Ratcliffe, 2003).”
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy (2015, background): “Additionally hypoxia induces ECs’ proliferation by regulation of VEGF-R1 (Flt-1), Ang-1 and Ang-2 expression.(67) iii) Finally, hypoxia and HIF-α support vessel maturation via induction of Ang-1, PDGF, and TGF-β to recruit supporting cells such as smooth muscle cells and pericytes creating mature an”