A receptor for phosphatidylserine-specific clearance of apoptotic cells

By Valerie Fadok, D. Bratton, D. M. Rose, A. Pearson, R. A. B. Ezekewitz, P. Henson. Nature, 2000

1,597 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/7bd41d95cdb954c39f056e96f0ddac3fa60bb319

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Arlene H. Sharpe
2. G. Dranoff
3. G. Freeman
4. K. Ravichandran
5. P. Barnes
6. P. Henson
7. U. Lorenz
8. Valerie Fadok

In Physiology

1. P. Henson
2. Valerie Fadok
3. Katsumori Segawa
4. S. Nagata
5. P. Barnes
6. S. Gordon

Citations in the corpus

• C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells (2001, background): “A number of other ligands and receptors may be active (19, 22–46), including a receptor for phosphatidylserine (47).”
• Phagocytosis and the actin cytoskeleton. (2001, background): “The recent report of a receptor for phosphatidylserine (Fadok et al., 2000), a membrane phospholipid exposed externally on apoptotic cells, is likely to stimulate rapid progress in this field.”
• Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. (2003, background): “PS, in turn, is recognized by a recently cloned PS Cleveland Clinic Foundation receptor whose blockade abrogates the engulfment of Cleveland, Ohio 44195 apoptotic cells by macrophages (Fadok et al., 2000; 5 Department of Radiation Oncology Savill and Fadok, 2000).”
• JmjC-domain-containing proteins and histone demethylation (2006, background): “The mouse phoshatidylserine receptor ( PTDSR ) was originally identified in a screen for factors that bind phosphatidylserine during clearance of apoptotic cell”
• An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure. (2015, background): “[107] established a monoclonal antibody (mAb 217) that bound human and mouse macrophages and inhibited apoptotic cell engulfment.”
• TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. (2007, methodology): “Phospholipid-Liposome Preparation Small unilamellar liposomes containing the indicated phospholipids(s) (Avanti Polar Lipids) were made as described previously (Fadok et al., 2000).”
• Resolution of inflammation: the beginning programs the end (2005, neutral): “Phosphatidylserine-recognition structures may also directly engage apoptotic cells, although these molecules require further characterizatio”
• Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. (2002, background): “We have recently suggested that exposed PS is crucial in the recognition and uptake of apoptotic cells and subsequent production of TGF-β1 (4).”
• Engulfment of apoptotic cells: signals for a good meal (2007, background): “Blocking the recognition of PtdSer that is exposed on apoptotic cells or stimulation of phagocytic cells with PtdSer-containing liposomes attenuates the anti-inflammatory immune response that is induced by apoptotic-cell engulfmen”
• A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. (2007, background): “Suspension cultures were further examined for phosphatydilserine (PS) exposure, an eat-me signal that activates phagocytosis of dying cells (Fadok et al., 1992, 2000), by labeling with a fluorescently tagged Annexin V protein that binds to PS.”