JmjC-domain-containing proteins and histone demethylation

By R. Klose, E. Kallin, Yi Zhang. Nature reviews genetics, 2006

1,278 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/26c33c6905ab670486046089ff6908af30206543

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, positive): “Interestingly, inactivating mutations in the TCA cycle enzymes, fumarate hydratase (FH) and succinate dehydrogenase (SDH), or tumor-associated missense mutations in IDH1/2 result in accumulation of high concentrations of fumarate, succinate, and the oncometabolite 2-hydroxyglutarate (2-HG), all of w”
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. (2007, neutral): “SMCX is evolutionarily conserved, and in mammals, it is a member of a subfamily of four proteins, including SMCY (JARID1D), RBP2 (JARID1A), and PLU-1 (JARID1B) (Klose et al., 2006a).”
Understanding the language of Lys36 methylation at histone H3 (2012, neutral): “We highlight the specificity, regulation and functional role of the enzymes that methylate H3K36, but we refer readers to informative reviews for a detailed discussion of the counteracting demethylase”
Stability and flexibility of epigenetic gene regulation in mammalian development (2007, background): “, but these marks could presumably be rapidly removed by enzymatic demethylation of H3K27 (by an unidentified demethylase”
Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma (2018, positive): “A highly conserved part containing the JmjC (Jumonji C) domain was characterized to reserve histone demethylase activity [10].”
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011, background): “…showed that mutant IDH enzymes predominantly acquire a neomorphic function to produce 2-HG, an oncometabolite that impairs catalytic activity of many Fe(II)- and 2OGdependent dioxygenases, including the JmjC family of histone demethylases (Klose et al. 2006) and the Tet family of DNA hydroxylases.”
Active DNA demethylation: many roads lead to Rome (2010, background): “In fact, numerous histone demethylases that can break a carbon–nitrogen bond have recently been discovere”
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers (2007, background): “Jumonji domain–containing protein-2A (JMJD2A, also known as JHDM3A) has JmjN and JmjC domains, which are required for its lysine demethylase activity, and two tudor domains, now classified as a double tudor domai”
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway (2010, background): “A highly-conserved family of proteins containing the JmjC domain was recently characterized to possess a histone demethylase activity [5].”