Engulfment of apoptotic cells: signals for a good meal

By K. Ravichandran, U. Lorenz. Nature reviews. Immunology, 2007

683 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/3ba091b062f091b4fed25f75ac22ea026c7393c9

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In Immunology

1. Guido Kroemer
2. L. Zitvogel
3. U. Hanisch
4. Douglas R. Green
5. J. Swanson
6. I. Tabas
7. R. Medzhitov
8. T. Ferguson

Citations in the corpus

• Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis (2011, background): “The membrane lipid, phosphatidylserine, has a key role in initiating the removal of apoptotic bodies by phagocytosis (Ravichandran and Lorenz, 2007) and clearance of certain viruses by macropinocytosis (Mercer and Helenius, 2008).”
• Apoptotic cells promote their own clearance and immune tolerance through activation of LXR (2009, neutral): “The resulting inflammation and stimulation of adaptive immune responses against self-antigens may ultimately trigger autoimmunity (Ravichandran and Lorenz, 2007; Savill et al., 2002).”
• Leishmaniasis: complexity at the host–pathogen interface (2011, background): “As apoptotic neutrophils are phagocytosed through receptor-mediated pathways that fail to trigger macrophage defence response”
• Macrophage death and defective inflammation resolution in atherosclerosis (2009, background): “What are the molecular mechanisms of efferocytosis in advanced atheroma? And what goes wrong in this setting? Efferocytosis involves a complex interplay between several sets of proteins that enable the recognition and engulfment of apoptotic cells by phagocyte”
• Immunogenic and tolerogenic cell death (2009, background): “Disruption or blockade of CD14, CD26, β3 integrin, β5 integrin or mannose-binding lectin, all of which are associated with the uptake of dying cells ( Box 4 ), leads to the accumulation of apoptotic bodies but does not result in autoimmunit”
• The role of defective clearance of apoptotic cells in systemic autoimmunity (2010, background): “Clearance of apoptotic cells In higher organisms, billions of apoptotic cells generated during the maintenance of homeostasis are rapidly and efficiently removed by professional phagocytes in an immunologically silent way”
• Programmed Cell Death in Animal Development and Disease (2011, neutral): “The engulfment process can be divided into the following stages: (1) sensing of the apoptotic cell, (2) recognition by the phagocyte, (3) internalization of target cell, (4) ingestion, and (5) postengulfment response of the phagocyte (Ravichandran and Lorenz, 2007).”
• The importance of natural IgM: scavenger, protector and regulator (2010, background): “Conversely, the removal of apoptotic cells can generate an immunoregulatory milieu and promote the resolution of inflammatio”
• Origin and physiological roles of inflammation (2008, background): “Macrophages recognize all apoptotic cells (regardless of how apoptosis is induced) by detecting phosphatidylserine at the surface of these cell”
• Shaping cups into phagosomes and macropinosomes (2008, background): “Signalling molecules that are essential to the phagocytosis of apoptotic cells have been identified through genetic and molecular studies of Caenorhabditis elegans , Drosophila melanogaster and mammalian cell”