A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion.

By M. Overholtzer, A. Mailleux, G. Mouneimne, G. Normand, S. Schnitt, R. King, E. Cibas, J. Brugge. Cell, 2007

695 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/4e18fa1f1f30fb20bba1a52621b3c8dba28a61c7

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Citations in the corpus

Classification of cell death (2005, critical): “In rare cases, however, internalized cells are able to divide within the engulfing cell or are released.(87) Hence, it is difficult to know whether the cellin-cell morphology (entosis) truly represents a novel cell death modality.”
Regulated cell death (RCD) in cancer: key pathways and targeted therapies (2022, background): “Its mediated internal cell death is mainly lysosomal mediated caspase-3 (cysteine protease-3) - independent death.(401) Some studies have found that it negatively regulates the formation of adhesion protein family molecule pcdh7 in entotic cell-in-cell structure and also found that the force ring pl”
Neuronal Cell Death. (2018, neutral): “” Entosis was originally defined as the process of one cell invading into another cell without cell death (529), but it can lead to death of the invading or invaded cell, so we have the concept of “entotic cell death” (366) or “cell-in-cell death” (716).”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “anchorage-independent growth of malignant cells [694].”
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 (2011, background): “In 2007, Overholtzer et al.130 introduced the term ‘entosis’ to describe a cell death mechanism linked to the ‘cell-in-cell’ phenotype that is frequently exhibited by nonphagocytic cells in clinical tumor samples.”
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 (2014, background): “Indeed, it has been reported that engulfed cells can be released from phagosomes as they preserve their viability, at least under some circumstances.(15) Thus, the NCCD recommends here to consider as dead only cells that either exhibit irreversible plasma membrane permeabilization or have undergone ”
Cell Death Signaling. (2015, background): “Untransformed breast epithelial cells that lose attachment to a substrate can engulf each other, resulting in the death of the engulfed cell by entosis (Overholtzer et al. 2007).”
Lysosomal membrane permeabilization and cell death (2018, background): “Entosis is another type of regulated cell death that requires lysosomes.(130) This process involves the engulfment of viable cells by nonphagocytic cells, and has been observed in epithelial cell cultures and human tumors.”