Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow.

By Y. Shiozawa, E. Pedersen, Aaron M. Havens, Younghun Jung, A. Mishra, Jeena Joseph, J. K. Kim, Lalit R. Patel, C. Ying, A. M. Ziegler and 7 more. Journal of Clinical Investigation, 2011

703 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/212944e891e59bdb59298a6b7a8a9b18a523ddbb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. Zena Werb
2. V. Plaks
3. Arthur W. Lambert
4. R. Weinberg
5. D. Pattabiraman

In Immunology

1. V. Plaks
2. R. Weinberg
3. Arthur W. Lambert
4. D. Pattabiraman
5. Niwen Kong
6. Zena Werb
7. Pengfei Lu

In Oncology

1. Zena Werb
2. D. Pattabiraman
3. Arthur W. Lambert
4. V. Plaks
5. R. Weinberg
6. Niwen Kong
7. Raghu Kalluri
8. D. Hanahan

Citations in the corpus

• The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, positive): “…are all able to alter their gene expression to resemble cell types that are not part of their original lineage (Quail et al., 2012) exemplifies cancer cell plasticity that enables cancer cells to gain/lose stem cell properties (Shirakawa et al., 2002; Passalidou et al., 2002; Lim et al., 2009).”
• EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “…to the bone, where these carcinoma cells have been found to compete with hematopoietic stem cells (HSC) for occupancy of sites in the endosteal niche; this occurs via the CXCL12-CXCR4 signaling axis that is normally reserved for the physiologic regulation of HSCs (Shiozawa et al., 2011).”