The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

By Rosa M. Canet-Avilés, M. Wilson, David W. Miller, Rili Ahmad, C. McLendon, Sourav Bandyopadhyay, M. Baptista, D. Ringe, G. Petsko, M. Cookson. Proceedings of the National Academy of Sciences of the United States of America, 2004

1,137 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/7a01fa08539cde3bf15e9640bf999fe2c5421ec8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. M. Beal
2. Valina L. Dawson
3. T. Dawson
4. M. Mouradian
5. V. Dias
6. E. Junn
7. Xiongwei Zhu
8. Olga Vitek

In Neurology

1. Valina L. Dawson
2. T. Dawson
3. D. Selkoe
4. M. Beal
5. Christian Haass
6. A. Lutz
7. K. Winklhofer
8. Nicole Exner

In Nutrition and Dietetics

1. D. Selkoe

Citations in the corpus

• Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases (2006, neutral): “C106 mutations prevent this mitochondrial relocalization and impair the cell's response to oxidative stress and mitochondrial damag”
• Genetics of Parkinson's disease. (2012, background): “The seven coding exons of the DJ-1 gene code for a 189-amino acid-long protein that is ubiquitously expressed and functions as a cellular sensor of oxidative stress (Canet-Aviles et al. 2004; Junn et al. 2005).”
• Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease (2012, background): “Interestingly, oxidative stress induces rapid relocalization of DJ-1 to mitochondria [181,182], suggesting that mitochondria could be a site of neuroprotective action for DJ-1.”
• The Role of Oxidative Stress in Parkinson’s Disease (2013, background): “Whether Cys106 oxidation is essential for the localization of DJ-1 to mitochondria in response to oxidative stress is controversial [346, 365, 366].”
• Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues (2015, background): “PARK7 plays an important role in mitochondrial oxidative stress (45); the drug-adduct detected at PARK7’s active site (C106) likely inhibits its function (46).”
• Dopamine covalently modifies and functionally inactivates parkin (2005, background): “These data are notable given the interest in DJ-1 cysteine oxidatio”
• Oxidative Stress: A Key Modulator in Neurodegenerative Diseases (2019, background): “DJ-1 is found to play as a marker and sensor for oxidative stress, as well as a redox-chaperone protein [117,118].”
• Molecular pathophysiology of Parkinson's disease. (2005, background): “A recent study has shown that oxidative stress promotes cysteine sulfinic acid-driven mitochondrial localization of DJ-1 and subsequent protection against mitochondria-dependent cell death (Canet-Aviles et al. 2004).”