A microRNA polycistron as a potential human oncogene

By Lin He, J. Thomson, M. Hemann, E. Hernando-Monge, D. Mu, Summer G. Goodson, S. Powers, C. Cordon-Cardo, Scott W. Lowe, Gregory J. Hannon and 1 more. Nature, 2005

3,810 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/77ef9aac7e0199184cb3169ac5e4de1d5fd7152b

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Citations in the corpus

MicroRNA signatures in human cancers (2006, background): “showed that enforced expression of the miR-17-92 cluster accelerated MYC -induced lymphomagenesi”
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure (2008, background): “Emerging evidence suggests that miRNAs play important roles in a variety of biological processes, including cancer and stem cell biology (6, 7).”
microRNAs in cancer (2013, background): “Retroviral overexpression of the cluster accelerated Myc-induced lymphoma formation (62), and in vivo dissection of the cluster’s activity demonstrated that miR-17/92 tumorigenic activity depends on the presence of the miR-19 seed family (74, 75).”
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis (2020, background): “Usually, the oncomiRs tend to be excessively represented (for example miR-17-92 or miR-21 clusters) [110,111], while the miRNAs with tumor suppression function (let-7 cluster), are expressed insufficiently [112].”
MicroRNAs in cell proliferation, cell death, and tumorigenesis (2006, methodology): “In a recent study, He et al (2005) found that miRNAs from this cluster are highly expressed in B-cell lymphoma samples and cell lines.”
A novel and universal method for microRNA RT-qPCR data normalization (2009, background): “Taken together with the fact that the miR17-92 cluster is transcribed as a single transcript (pri-miR-1792) [22], most likely all miRNAs should be activated in the MNA NB cells.”
Control of Embryonic Stem Cell State (2011, background): “These include the mir-290-295 cluster, and miRNAs with seed sequences in this family have been implicated in cell proliferation (He et al., 2005; O’Donnell et al., 2005; Wang et al., 2008) and have been shown to rescue the proliferation defects observed in miRNA-deficient ES cells (Kanellopoulou et…”
Genomic profiling of microRNA and mRNA reveals deregulated microRNA expression in prostate cancer (2008, background): “The miR-106b-25 cluster has extensive homologue with two other microRNA clusters that are candidate human oncogenes, the miR-17-92 cluster and the miR106a-363 cluster (22, 24).”
miRiad roles for the miR-17-92 cluster in development and disease. (2008, result): “genic activity (He et al., 2005).”
MicroRNAs in development and disease. (2011, background): “As indicated above, myc also induces miR17 92 expression, which enhances the development of myc-induced pre-B cell lymophoma (240).”
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. (2008, methodology): “cDNAs were subsequently subcloned into pMSCV-puro-IRES-GFP (He et al. 2005).”
A MicroRNA Signature of Hypoxia (2006, background): “MicroRNAs represent approximately 1% to 2% of the eukaryotic transcriptome and have been shown to play critical roles in the coordination of cell differentiation, proliferation, death, and metabolism (1, 3, 6, 7, 17, 24) and more recently in tumorigenesis (2, 5, 6, 10, 13, 20, 21).”