Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing.

By Martin A. Newman, J. Thomson, Scott M. Hammond. RNA: A publication of the RNA Society, 2008

767 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7537cea85832e1cce93b2efcbe514f1c1775d925

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Citations in the corpus

Non-coding RNAs as regulators of embryogenesis (2011, background): “This enigma has been resolved by the discovery that the pluripotency factor LIN28 binds to a short tetranucleotide binding motif in the terminal loop of let-7 miRNA precursors and blocks their processing by Drosh”
Oncogenic Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms (2011, unknown): “Lin28B Regulates let-7 Expression through a Zcchc11-Independent Mechanism The paralogous RNA-binding proteins Lin28A and Lin28B have a high degree of sequence identity and conserved domain organization (Figure 1A), and both proteins selectively block let-7 expression (Newman et al., 2008; Viswanatha”
MicroRNAs: key regulators of stem cells (2009, background): “These findings also establish a novel role for the miRNA-precursor loop region in the regulated production of mature let-7 (Ref”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “Another target for cancer therapy are the recently discovered regulators of let-7 processing LIN28 and LIN28B (which happens to be LOG3) (Newman et al., 2008; Viswanathan et al., 2008).”
An overview of microRNAs (2015, background): “[131] I. Heo, C. Joo, Y.K. Kim, M. Ha, M.J. Yoon, J. Cho, K.H. Yeom, J. Han, V.N. Kim, TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation, Cell, 138 (2009) 696-708.”
Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “Although LIN-28 was then found to block accumulation of mature let-7 by repression of both Drosha and Dicer activities (Heo et al., 2008; Newman et al., 2008; Rybak et al., 2008; Viswanathan et al., 2008), recent studies demonstrate that LIN-28 can induce 30 terminal uridylation of pre-let-7 miRNA…”
miRNAs in human cancer (2010, background): “First, LIN28A blocks processing of tumour suppressor pri- and pre-let-7 [81–85], thus maintaining expression of genes that drive self-renewal and proliferation (reviewed in [86]); tumours that express LIN28A were indeed shown to be poorly differentiated and more aggressive than LIN28A-negative tumou”
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. (2008, background): “The mouse homolog of Lin28a was recently reported to interfere with either Drosha processing of pri-let-7 (Newman et al., 2008; Viswanathan et al., 2008) or Dicer processing of pre-let-7 (Rybak et al.”
microRNAs in action: biogenesis, function and regulation (2023, background): “One of the first cases of regulated miRNA biogenesis regards the control of let-7 family maturation by Lin28 RBPs 114–117 (Fig.”
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. (2009, background): “It has been suggested that Lin28 specifically recognizes the terminal loop of pre-let-7 (Newman et al., 2008; Piskounova et al., 2008).”
Biological principles of microRNA-mediated regulation: shared themes amid diversity (2008, background): “For example, the RNA-binding protein LIN-28 was recently shown to inhibit the maturation of let-7-family miRNA”