Integrating mRNA processing with transcription.

By N. Proudfoot, A. Furger, M. Dye. Cell, 2002

1,107 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/775680cac4967ddf083f4ddcd9c96d914cfc1d15

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In Molecular Biology

Citations in the corpus

Optical Control of Mammalian Endogenous Transcription and Epigenetic States (2013, background): “Although the interaction between CRY2 and CIB1 occurs on a sub-second timescale 6 , LITE-mediated transcriptional activation is likely dependent on many factors, including rate of transcription, mRNA processing, and transcript stability 24,25 .”
HITS-CLIP yields genome-wide insights into brain alternative RNA processing (2008, neutral): “Numerous links have been made between pre-mRNA splicing and 3 ′ -end processing44,45, such as the observation that the splicing factor sex-lethal can regulate polyadenylation by competing with CstF64 for RNA binding46.”
How introns influence and enhance eukaryotic gene expression. (2003, background): “In contrast to capping, 30-end formation is reciprocally linked to splicing [ 8 ].”
Elongation by RNA polymerase II: the short and long of it. (2004, background): “It is now established that the RNAP II CTD plays a central role in recruiting protein factors involved in elongation, as well as in mRNA maturation, surveillance, and export (Hirose and Manley 2000; Orphanides and Reinberg 2002; Proudfoot et al. 2002).”
Pre-mRNA splicing and human disease. (2003, background): “Although purified Sm proteins assemble on snRNAs in an ordered pathway in vitro in the absence of non-snRNP factors (Raker et al. 1996), the SMN complex could be required for efficient core assembly in the complex cellular environment or to regulate snRNP assembly in response to cellular metabolism.”
The RNA polymerase II CTD coordinates transcription and RNA processing. (2012, background): “These processes are frequently coupled with transcription, and all involve the CTD (for review, see Hirose and Manley 2000; Maniatis and Reed 2002; Proudfoot et al. 2002).”
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. (2007, background): “A current view of mRNA biogenesis incorporates multiple events simultaneously, including transcript elongation, CAP addition, pre-mRNA splicing, and polyadenylation, in addition to mRNA surveillance and export (Hirose and Manley, 2000; Maniatis and Reed, 2002; Orphanides and Reinberg, 2002; Proudfoo”
Splicing factor SF3b as a target of the antitumor natural product pladienolide (2007, background): “These steps are coupled extensively to form 'gene expression factories”
Genomic variants in exons and introns: identifying the splicing spoilers (2004, background): “In human cells, transcription and splicing are coordinately regulated in the nucleus in both a temporal and a spatial fashio”
Pre-mRNA splicing: awash in a sea of proteins. (2003, background): “the case for functional coupling between splicing and other steps in pre-mRNA/mRNA metabolism (Maniatis and Reed, 2002; Proudfoot et al., 2002).”
Mechanisms and consequences of alternative polyadenylation (2011, positive): “The coupling between transcription and 30 processing is well established (reviewed in Hirose and Manley, 2000; Perales and Bentley, 2009; Proudfoot et al., 2002).”
A quantitative atlas of polyadenylation in five mammals (2012, background): “Furthermore, extensive usage of tissue-specific sites, some of which are associated with cis-regulatory elements, suggests that alternative polyadenylation is tightly regulated (Proudfoot et al. 2002) and has important physiological implications.”
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. (2004, background): “Splicing is known to enhance the efficiency of polyadenylation (Proudfoot et al. 2002) and might therefore permit the use of “weak” poly(A) sites in the VMP-1 mRNA that are not effectively recognized when present in the intronless primiR-21 transcript.”