How introns influence and enhance eukaryotic gene expression.
By Hervé Le Hir, Ajit Nott, Melissa J. Moore. TIBS -Trends in Biochemical Sciences. Regular ed, 2003
737 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3d03922366ed0d0fedfcd691728ac603fb549841
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In Molecular Biology
Citations in the corpus
- Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. (2007, background): “Considering that splicing is known to enhance steady-state translation (Le Hir et al. 2003), an intron upstream of a PTC may be required for an efficient pioneer round of mRNA translation; i.e., efficient PTC recognition during the time mRNA is bound by the requisite NMD factors (see below).”
- Toxin–antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes (2005, background): “The NMD pathway is triggered during the first round of translation of the aberrant mRNA thus ensuring that synthesis of truncated, potentially harmful proteins is prevented (1,2).”
- Pre-mRNA processing reaches back to transcription and ahead to translation. (2009, positive): “Splicing Makes for Better Translation Another well-documented effect of splicing on cytoplasmic mRNA metabolism is enhanced translational efficiency (Le Hir et al., 2003; Le Hir and Seraphin, 2008).”