Splicing factor SF3b as a target of the antitumor natural product pladienolide

By Y. Kotake, K. Sagane, T. Owa, Y. Mimori-Kiyosue, H. Shimizu, Mai Uesugi, Yasushi Ishihama, Masao Iwata, Y. Mizui. Nature Chemical Biology, 2007

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Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15 (2017, background): “One example is the pladienolide class of natural products, which potently disrupts the early stage of spliceosome assembly by targeting the canonical splicing factor SF3B complex (45).”
Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila (2015, neutral): “ELAV targets are strongly Kotake et al. 2007), showing the interactions between core proteins of the U2 snRNPand the RBPs fromthis study.”
Small molecule modulators of pre-mRNA splicing in cancer therapy (2015, background): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript Table 1 Small molecule pre-mRNA splicing modulators Compound name Inhibition target Observations Reference FR901464 (SSA) SF3B1 Inhibition o”