Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.

By L. Desbonnet, L. Garrett, G. Clarke, B. Kiely, J. Cryan, Ted G. Dinan. Neuroscience, 2010

925 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacy, Social Psychology

View Paper: https://www.semanticscholar.org/paper/770b6408a77bc48fc4e0471f8cf050e5d926d84f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. Yan Wang
5. L. Kasper
6. S. Mazmanian
7. T. Sampson
8. C. Stanton

In Pharmacy

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. S. Mazmanian
5. C. Stanton
6. T. Sampson
7. P. Kennedy
8. J. Foster

In Social Psychology

1. J. Cryan
2. Ted G. Dinan
3. S. Mazmanian
4. T. Sampson
5. G. Clarke
6. C. Stanton
7. Yan Wang
8. L. Kasper

Citations in the corpus

• Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior (2012, background): “Finally, administration of the probiotic Bifidobacterium infantis to maternally separated rats was found to reverse depressive-like behavior in the FST, reduce peripheral IL-6 concentrations, and normalize basal norepinephrine concentrations in the brainstem (Desbonnet et al, 2010).”
• The Central Nervous System and the Gut Microbiome (2016, background): “Depression Evidence in rodentmodels suggest that thegutmicrobiomeplays a role in depressive-like behaviors (Bravo et al., 2011; Desbonnet et al., 2010; Mello et al., 2013).”
• Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. (2016, background): “Different lactobacillus and bifidobacteria species have been shown to modulate depression and stress-related behaviours in animal models (Bravo et al., 2011; Desbonnet et al., 2010; Savignac et al., 2015).”
• Stress & the gut-brain axis: Regulation by the microbiome (2017, methodology): “Maternal separation is frequently used as a model of early life stress that provokes an adult depressive and anxiety-like phenotype, along with alterations in monoamine turnover, immune function and HPA axis activation (O'Mahony et al., 2009; O'Mahony et al., 2011; Desbonnet et al., 2010).”
• Control of Brain Development, Function, and Behavior by the Microbiome (2015, positive): “This could include a range of disorders, from neurodegenerative diseases like Parkinson’s disease, which is treated with oral L-DOPA to stimulate dopamine levels, to depression which is commonly treated with SSRIs, that increase the concentration of 5-HT available to signal in the synapse.”
• Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour. (2015, background): “Considering that specific probiotic treatments can ameliorate depressive-like behaviours (Desbonnet et al., 2010; Bravo et al., 2011), anxiety and communication deficits (Hsiao et al.”
• Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice. (2017, positive): “A previous study showed that a specific bacterial strain, Bifidobacterium infantis, attenuated the exaggerated interleukin 6 response to concanavalin A stimulation in rats after early-life stress (55).”
• Psychobiotics: a novel class of psychotropic. (2013, background): “(68) assessed the potential benefits of the probiotic B.”
• Gut microbiome-host interactions in health and disease (2011, background): “A recent study assessed the potential benefits of the probiotic Bifidobacterium infantis in the rat maternal separation model [91].”