Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour.

By L. Desbonnet, G. Clarke, Alexander Traplin, Orla O'Sullivan, F. Crispie, R. Moloney, Paul D. Cotter, Ted G. Dinan, J. Cryan. Brain, behavior, and immunity, 2015

680 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/17b67d5f69355344709d843347244d949c180cd2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. J. Cryan
2. Ted G. Dinan
3. T. Sampson
4. C. Nemeroff
5. Eléonore Beurel
6. G. Clarke
7. S. Mazmanian
8. M. Toups

In Biological Psychiatry

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. S. Mazmanian
6. T. Sampson
7. C. Nemeroff
8. Eléonore Beurel

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. T. Sampson
6. S. Mazmanian
7. A. Farzi
8. C. Nemeroff

Citations in the corpus

• The Central Nervous System and the Gut Microbiome (2016, background): “…noradrenaline in hippocampus and increased L-DOPA in amygdala; decreased BDNF in the hippocampus and vasopressin expression in the hypothalamus Desbonnet et al., 2015 Germ-free animals deficits in memory formation decreased BDNF and c-Fos expression in the CA1 region of the…”
• The Gut Microbiota and Alzheimer’s Disease (2017, neutral): “From weaning onwards, disruption of the gut microbiotaafterantibiotictreatmentreducedanxiety-likebehaviorandinducedcognitiveimpairment accompaniedbysignificantlydecreasedBDNFlevels intheadultbrain[54].”
• Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice. (2017, neutral): “Indeed the microbiota plays an important role in neurodevelopment, leading to alterations in gene expression in critical brain regions, and resulting in perturbation to the programming of normal social and cognitive behaviors in mice (3-6).”
• The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “Similarly, antibiotic treatments alter multiple behaviors of mice, suggesting that bacteria influence neurobehavioral outcomes (Desbonnet et al., 2015; Hao et al., 2013; Hoban et al., 2016; Majidi et al., 2016; O’Mahony et al., 2014; Wang et al., 2017).”
• Stress & the gut-brain axis: Regulation by the microbiome (2017, neutral): “Interestingly, the reduced anxiety-like behaviour was accompanied by cognitive deficits, reduced levels of hippocampal brain-derived neurotrophic factor (BDNF) mRNA, and reduced levels of oxytocin and vasopressin in the hypothalamus (Desbonnet et al., 2015).”
• Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, methodology): “treatment (Desbonnet et al., 2015; Fr€ ohlich et al., 2016) dietary manipulation (Li et al.”
• Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration (2017, background): “Indeed, at a behavioural level, post-weaning depletion of the gut microbiota led to reduced anxiety coupled with cognitive deficits (Desbonnet et al. 2015).”
• Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain. (2019, background): “Alterations in the gut microbiota composition and metabolic activities are closely associated with changes in brain functions and behaviors (2, 12, 51).”