FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.

By B. Ciruna, Janet Rossant. Developmental Cell, 2001

720 citations recorded by the source corpus.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/76d34fc3e4738f887198ddee28ab75cbd1b7feed

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. Weinberg
2. M. Nieto
3. Jing Yang
4. J. P. Thiery
5. Jormay Lim
6. R. Huang
7. J. Sleeman
8. W. Birchmeier

In Surgery

1. M. Nieto
2. J. P. Thiery
3. R. Weinberg
4. W. Nelson
5. H. Acloque

Citations in the corpus

• Epithelial-mesenchymal transitions in development and disease. (2009, background): “They are induced by TGFβ superfamily members, and FGF signaling is necessary to maintain their expression and for gastrulation to proceed (Barrallo-Gimeno and Nieto, 2005; Ciruna and Rossant, 2001).”
• Mechanisms underlying differential responses to FGF signaling. (2005, result): “Evidence to support this model comes from studies on FGFR1 null mouse embryos in which Wnt signaling is repressed, suggesting that FGFR1 indirectly promotes Wnt signaling at the primitive streak [109].”
• Vertebrate Endoderm Development and Organ Formation (2009, background): “In the mouse gastrula, FGF signaling, MAP kinase, and Eomes are required to downregulate E-cadherin and allow epiblast cells to undergo an EMT and ingress through the PS (Arnold et al. 2008, Ciruna & Rossant 2001, Zohn et al. 2006).”
• Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. (2008, background): “For example, FGFR1 orchestrates the EMT and morphogenesis of mesoderm at the primitive streak by controlling E-cadherin expression in mice (Ciruna and Rossant, 2001).”
• Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis (2003, background): “Mesoderm formation during gastrulation involves FGFs and BMPs, as well as proteins that positively or negatively regulate the processing, secretion or activity of both factor type”
• Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. (2010, background): “In FGFR1-deficient epiblasts, the expression of the Wnt target Brachyury is negatively affected, but lowering E-cadherin levels rescues Brachyury expression in the primitive streak (Ciruna and Rossant 2001).”
• Epithelial-mesenchymal transitions: insights from development (2012, background): “…expressions of FGF8, Nodal and Wnt3 (Du et al., 2010), crucial signaling proteins in gastrulation (Niswander and Martin, 1992; Crossley and Martin, 1995; Liu et al., 1999; Ciruna and Rossant, 2001; Yamamoto et al., 2001; Iratni et al., 2002; Norris et al., 2002; Garcia-Garcia and Anderson, 2003).”
• Making muscle: skeletal myogenesis in vivo and in vitro (2017, background): “In the absence of Wnt or FGF signaling, the mouse embryo is truncated and ectopic neural tissue forms in place of the posterior paraxial mesoderm (Boulet and Capecchi, 2012; Ciruna and Rossant, 2001; Takada et al., 1994).”
• Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo (2009, background): “Loss of FGFR1 also disrupts gastrulation, resulting in the expansion of the primitive strea”
• Complex networks orchestrate epithelial–mesenchymal transitions (2006, background): “FGF receptor-1 (FGFR1) signalling controls the expression of SNAI1, which inhibits E-cadherin transcriptio”
• Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. (2009, positive): “Sig - naling through FGF receptors (FGFRs) seems to be necessary to maintain the EMT regulatory network (25, 26).”