Epithelial-mesenchymal transitions in development and disease.

By J. P. Thiery, H. Acloque, R. Huang, M. Nieto. Cell, 2009

9,583 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/389ac3e28f10660aea3a40bd802473e3e9ef3407

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. Weinberg
2. M. Nieto
3. Jing Yang
4. Thomas Brabletz
5. K. Guan
6. J. P. Thiery
7. Rakesh K. Jain
8. R. Derynck

In Oncology

1. R. Weinberg
2. M. Nieto
3. Thomas Brabletz
4. Jing Yang
5. J. P. Thiery
6. Simone Brabletz
7. D. Medici
8. D. Hanahan

In Pulmonary and Respiratory Medicine

1. J. P. Thiery
2. R. Weinberg
3. Jormay Lim
4. M. Nieto
5. Thomas Brabletz
6. Youhua Liu
7. Sumera I. Ilyas
8. R. Huang

Citations in the corpus

• The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, background): “…of the TGF-β superfamily: Wnts, Notch, epithelial growth factor (EGF), hepatocyte growth factor (HGF), fibroblast growth factor (FGF), hypoxia-inducible factor (HIF), Sonic hedgehog (Shh), and others (as discussed in detail in excellent reviews, e.g., De Craene et al. 2005, Thiery & Sleeman 2006).”
• Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast (2011, background): “An array of contextual signals has been implicated in the induction of an EMT, almost invariably in cells that have undergone unknown predisposing genetic changes (Thiery et al., 2009).”
• Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways (2011, background): “This multi-step process results in the loss of cell-to-cell adhesive properties, loss of cell polarity, and the gain of invasive and migratory mesenchymal properties”
• Management of acquired resistance to EGFR TKI–targeted therapy in advanced non-small cell lung cancer (2018, neutral): “Different EMT transcription factors, including Slug, ZEB1, Snail, and AXL, changed with the development of acquired resistance to EGFR TKIs [42, 44].”
• Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization (2011, background): “2401" language="eng" relation="no"> Early events of metastatic dissemination are thought to be initiated by epithelial-to-mesenchymal transition (EMT) in carcinoma cells, promoting tumor cell migration and invasio”
• The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “Tissue regeneration is associated with organ fibrosis and disease progression and ultimately causes organ failure [21].”
• Loss of FBP1 by Snail-mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer (2013, neutral): “The increased motility and invasiveness of metastatic tumor cells are reminiscent of the events that occur at the epithelial-mesenchymal transition (EMT), a characteristic of embryonic development, tissue remodeling and wound healing (Polyak and Weinberg, 2009; Thiery et al., 2009).”
• The Roles of Autophagy in Cancer (2018, background): “These processes induce metastasis of cancer, leading to a lack of cell-cell adhesion, cell polarity to increase of cell motility, polarity, and invasiveness [111,112].”
• Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. (2010, background): “In addition, a process that often plays a role in the acquisition of invasive behavior in cancer cells, the epithelial-to-mesenchymal transition (EMT), is accompanied by a reprogramming of AS (Thiery et al. 2009).”
• The Hippo pathway: regulators and regulations. (2013, background): “YAP and TAZ induced an epithelial–mesenchymal transition (EMT), a phenomenon crucial for the initiation of cancer metastasis (Overholtzer et al. 2006; Lei et al. 2008; Thiery et al. 2009).”
• Distinct EMT programs control normal mammary stem cells and tumour-initiating cells (2015, neutral): “Indeed, Snail had been reported to activate Zeb1 expression in non-mammary types of epithelial cells 29,30 .”
• IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, background): “org Volume 124 Number 4 April 2014 ses (3, 42).”
• TGF-β1 Signaling and Tissue Fibrosis. (2018, background): “More insight has emerged with greater usage of fibrotic human tissue samples for biomedical research, the development of novel techniques for genetic modifications to mice, and a greater understanding of some of the prominent EMT signaling pathways (Kalluri and Neilson 2003; Teng et al. 2007; Kallur”