Vertebrate Endoderm Development and Organ Formation

By Aaron M. Zorn, James M. Wells. Annual Review of Cell and Developmental Biology, 2009

790 citations recorded by the source corpus.

The endoderm germ layer contributes to the respiratory and gastrointestinal tracts, and all of their associated organs. Over the past decade, studies in vertebrate model organisms; including frog, fish, chick, and mouse; have greatly enhanced our understanding of the molecular basis of endoderm organ development. We review this progress with a focus on early stages of endoderm organogenesis including endoderm formation, gut tube morphogenesis and patterning, and organ specification. Lastly, we discuss how developmental mechanisms that regulate endoderm organogenesis are used to direct differentiation of embryonic stem cells into specific adult cell types, which function to alleviate disease symptoms in animal models.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/434ee0ffa2cebb8276930e47d96ae16a93fde5d6

Citations in the corpus

• The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate (2013, neutral): “Furthermore, antagonism between the stomach-specifying Sox2/Barx1/Sfrp pathway and the intestinal fate-promoting Wnt/Cdx2 pathway is responsible for establishing the boundary between the glandular stomach and the intestine (Zorn and Wells, 2009).”