Epithelial-mesenchymal transitions: insights from development

By Jormay Lim, J. P. Thiery. Development, 2012

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Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients (2014, positive): “EMT was first described as a mechanism driving critical morphogenetic steps (for example, gastrulation) in the development of most metazoans (Jordan et al , 2011; Lim & Thiery, 2012) and, more recently, in wound-healing and carcinoma progression (Thiery et al , 2009).”
Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “First described in the 1980s as a cellular phenomenon in the primitive streak of chick embryos, EMT governs many developmental processes such as gastrulation, neural crest development, somite dissociation, and palate and lip fusion (1, 2).”
Braveheart, a long non-coding RNA required for cardiovascular lineage commitment (2013, background): “Snai1 and Snai2 repress E-cadherin, and the switch from E-cadherin to N-cadherin expression is a hallmark of EMT (Lim and Thiery, 2012).”
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “and coalesce into a single cell layer to form the basic epithelial tissue [27, 28].”