Dicer is essential for mouse development

By E. Bernstein, Sang Y. Kim, M. Carmell, E. Murchison, H. Alcorn, Mamie Z. Li, A. Mills, Stephen J. Elledge, K. Anderson, Gregory J. Hannon. Nature Genetics, 2003

2,064 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/76cfbb193c51108d2944f42dbc4f9c84333c33c7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. David P. Bartel
2. Scott M. Hammond
3. John S. Mattick
4. Phillip D. Zamore
5. V. Narry Kim
6. Phillip A. Sharp
7. Gregory J. Hannon
8. Frank J. Slack

In Molecular Biology

1. David P. Bartel
2. John S. Mattick
3. Richard A. Young
4. Phillip D. Zamore
5. V. Narry Kim
6. Scott M. Hammond
7. Phillip A. Sharp
8. Gregory J. Hannon

Citations in the corpus

• Small non-coding RNAs in animal development (2008, background): “Deletion of Dicer1 and Dgcr8 results in early developmental arrest in mice, accompanied by defects in the proliferation of pluripotent stem cell”
• MicroRNA functions in animal development and human disease (2005, background): “Pre-miRNAs are exported from the nucleus by Exportin-5 (Bohnsack et al., 2004; Lund et al., 2003; Yi et al., 2003).”
• microPrimer: the biogenesis and function of microRNA (2005, background): “elegans, abnormal embryonic morphogenesis in zebrafish and stem-cell differentiation defects in mice (Knight and Bass, 2001; Park et al., 2002; Bernstein et al., 2003; Wienholds et al., 2003; Giraldez et al., 2005; Hatfield et al., 2005).”
• The neuronal microRNA system (2006, background): “5, consistent with the model that dicer products might be crucial for embryonic patterning and morphogenesi”
• Role of microRNAs in vascular diseases, inflammation, and angiogenesis. (2008, background): “Indeed, Dicer is essential for early mouse development.(20) During embryogenesis, Dicer is required for normal skeletal muscle development.”
• Single processing center models for human Dicer and bacterial RNase III. (2004, methodology): “Based on an X-ray structure of siRNAs by C. elegans and Drosophila Dicers is greatly of the Aquifex aeolicus RNase III, models of the enstimulated by the addition of ATP ( Bernstein et al., 2001; zyme interaction with dsRNA, and its cleavage at two”
• The role of RNA interference in heterochromatic silencing (2004, background): “Dicer -null mice arrest very early in development, and this has been attributed to a defect in stem-cell maintenanc”
• Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (2008, methodology): “…differentiated cells from EBs were chosen for miRNA profiling, first because the pluripotency of ESCs is known to require the presence of miRNAs (Bernstein et al. 2003; Song and Tuan 2006; Wang et al. 2007) and second because specific changes in miRNA expression are thought to accompany…”
• Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, background): “In mice, deletion of this evolutionarily conserved endonuclease leads to lethality early in developmen”
• Origin, biogenesis, and activity of plant microRNAs. (2009, positive): “miRNA-deficient mutants in both kingdoms exhibit severe developmental defects because they fail to acquire appropriate cell identities during embryonic and post-embryonic growth (Bernstein et al., 2003; Jacobsen et al., 1999).”
• Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein (2005, neutral): “5, apparently devoid of stem cells [62].”