Small non-coding RNAs in animal development

By G. Stefani, Frank J. Slack. Nature reviews. Molecular cell biology, 2008

1,381 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/fb5e013f1b173752d176b2b85c999dcc018ed9cc

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Citations in the corpus

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis (2010, background): “…nt in length, which bind to the 3 UTR of target genes and thereby repress translation of target genes and/or induce degradation of target gene mRNA (Stefani and Slack, 2008). miRNAs play essential roles in numerous cellular and developmental processes, including intracellular signaling pathways…”
Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression (2010, background): “In addition, recently noncoding RNAs, including microRNAs, have been implicated in EMT in cancer and development [93, 94].”
Exosomes from Human Saliva as a Source of microRNA Biomarkers (2009, positive): “microRNAs are a group of small RNAs, 19–25 nucleotides in length, involved in the regulation of development and cell differentiation, proliferation and survival (Guarnieri and DiLeone, 2008; Lodish et al, 2008; Stefani and Slack, 2008).”
Epithelial-mesenchymal transitions in development and disease. (2009, background): “Indeed, they have been implicated in neuronal, muscle, and germline development (Stefani and Slack, 2008).”
Macrophage phenotypes in atherosclerosis (2014, background): “Upon binding to the 30-untranslated region (UTR) of target mRNAs, miRNAs negatively regulate gene expression by blocking the translation process or by increasing mRNA degradation (122).”
miRiad roles for the miR-17-92 cluster in development and disease. (2008, background): “tiple individual mature miRNAs (Stefani and Slack, 2008).”
RNA Sequencing and Analysis (2015, positive): “For instance, one such class of ncRNAs is small noncoding RNAs, which include microRNA (miRNA) and piwi-interacting RNA (piRNA), both of which regulate gene expression at the posttranscriptional level (Stefani and Slack 2008).”
MicroRNA control of signal transduction (2010, background): “Alternatively, miRNA functions may not be revealed under uniform laboratory conditions but may need more sophisticated experimental assays that take into account the cell's own complexity and the cell's interactions within tissues or organism”
Biological principles of microRNA-mediated regulation: shared themes amid diversity (2008, background): “The subsequent explosion of miRNA research in the current decade has yielded breathtaking advances in our understanding of the mechanism and biology of miRNA contro”
MicroRNAs in human cancer. (2013, background): “2 Alterations in RNASEN/DGCR8 and DICER1/TARBP2—Inhibition of the miRNA biogenesis pathway leads to severe developmental defects and is lethal in many organisms (reviewed earlier in [86], recent examples include [77, 78]), and perturbations of this pathway predispose to tumorigenesis [87].”
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. (2010, neutral): “miRNAs play roles in early development (Stefani and Slack, 2008) and in diseases such as cancer (Esquela-Kerscher and Slack, 2006) and neurodegeneration (Eacker et al.”
Hypoxia inducible mir-210 regulates normoxic gene expression involved in tumor initiation (2009, positive): “Recently, microRNAs (miRNAs) have emerged as a new class of noncoding genes involved in regulating cell proliferation, differentiation, and viability (Bartel, 2004; Stefani and Slack, 2008).”