Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives

By P. Rodriguez, Augusto Ochoa. Immunological Reviews, 2008

722 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/d97ba175c5fc8741d7af0d8a5498eab6327c84dd

How researchers see this paper

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In Immunology

1. D. Gabrilovich
2. T. Condamine
3. M. Munder
4. S. Galli
5. TA Wynn
6. Je-in Youn
7. S. Nagaraj
8. Cesar A. Corzo

In Neurology

1. D. Gabrilovich
2. S. Nagaraj
3. TA Wynn
4. M. Munder
5. J. Massagué
6. E. Batlle

Citations in the corpus

• Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function (2010, background): “The Larginine metabolism has been associated with MDSC suppression [14,15].”
• Arginase: an emerging key player in the mammalian immune system (2009, background): “This population is characterized by expression of CD11b and Gr-1 and efficiently suppresses T cell immune functions (Serafini et al., 2006a; Rodriguez and Ochoa, 2008).”
• Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils (2011, background): “Arginase I is probably one of the main suppressors of T cells, as deficiency in L -arginine inhibits T cell proliferation and functio”
• Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer (2013, background): “It has been reported that adequate levels of arginine in the extracellular milieu are crucial for T-cell proliferation and activity, and that reduction of arginine suppresses T-cell responses (Rodriguez et al, 2004; Rodriguez and Ochoa, 2008).”
• HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment (2010, background): “Extensive studies in recent years suggested several mechanisms of MDSC-mediated immune suppression that involve arginine (Bronte and Zanovello, 2005; Rodríguez and Ochoa, 2008) and cysteine (Srivastava et al.”
• Myeloid-derived-suppressor cells as regulators of the immune system (2009, positive): “MDSCs express high levels of both arginase 1 and iNOS, and a direct role for both of these enzymes in the inhibition of T-cell function is well established; this has been reviewed recentl”
• Polarization of Tumor-Associated Neutrophil (TAN) Phenotype by TGF-β: “N1” versus “N2” TAN (2009, background): “In both types of tumors, control TANs were found to have high levels of arginase, an important immunosuppressor of the adaptive immune system (Rodriguez and Ochoa, 2008).”