Selenium: biochemical role as a component of glutathione peroxidase.

By J. T. Rotruck, A. L. Pope, H. Ganther, A. Swanson, D. Hafeman, W. Hoekstra. Science, 2009

2,969 citations recorded by the source corpus.

Subfields: Insect Science, Nutrition and Dietetics, Plant Science

View Paper: https://www.semanticscholar.org/paper/74e38ad2cbe5f31a83b3bd7e730f17855d68504f

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Citations in the corpus

Effects of different dietary selenium sources (selenium nanoparticle and selenomethionine) on growth performance, muscle composition and glutathione peroxidase enzyme activity of crucian carp (Carassius auratus gibelio) (2009, background): “It was found to be an integral part of the glutathione peroxidase enzyme (Rotruck et al., 1973).”
Selenium in agriculture: a nutrient or contaminant for crops? (2014, background): “Selenium was reported to be an essential component of the enzyme glutathione peroxidase (GSH-Px) (Rotruck et al. 1973) and also iodotyronine deiodinase which catalyzes the thyroxine deiodination to triiodothyronine, the main biologically active thyroid hormone.”
Effects of different levels of dietary selenium nanoparticles on growth performance, muscle composition, blood biochemical profiles and antioxidant status of common carp (Cyprinus carpio) (2015, background): “Liver is themain site of Se accumulation infish (Hodson et al., 1980) and degeneration of liver tissue has been reported in fish exposed to Se (Sorensen et al., 1984).”
Nutrient Requirements Of Fish (2016, background): “Selenium is an integral part of the enzyme glutathione peroxidase ( Rostruck et al .”
Agronomic biofortification of Brassica with selenium—enrichment of SeMet and its identification in Brassica seeds and meal (2010, background): “Selenium (Se) is recognized as essential microelement for humans and animals, mainly due to its antioxidative properties and role in hormone balance (Schwartz and Foltz 1957; Flohe et al. 1973; Rotruck et al. 1973).”
Alleviation of temperature stress by nutrient management in crop plants: a review (2012, background): “Selenium was recognized as an essential trace element with a relatively low concentration range (Schwartz and Foltz, 1957) and its physiological role was established when it was shown to be one of the glutathione peroxidase (GPx) components (Rotruck et al., 1973).”
A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding (2009, background): “This polyphenol-bound iron would not be available to react with H2O2, and thus the H2O2 would be decomposed by catalase or peroxidase enzymes, such as glutathione peroxidase [273–275].”
Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities (2011, positive): “Subsequent analysis found that the trace mineral, selenium, in the form of the amino acid, Sec, is essential for the activity of GPx-1 (127, 203, 309, 312).”
Effects of dietary selenium nanoparticles on physiological andbiochemical aspects of juvenile Tor putitora (2016, background): “Selenium is involved in the formation of several types of selenoproteins, among which GSH-Px is the most important component of the immune system of the body (Rotruck et al., 1973).”
Selenium in global food systems (2001, background): “The nutritional essentiality of Se, therefore, appears to be due to the functions of SeCys proteins: antioxidant protection by the GPX, energy metabolism affected by the iodothyronine 5 0-deiodinases, and redox regulation of transcriptional factors and gene expression by the thioredoxin reductases.”
Rapid, room-temperature synthesis of amorphous selenium/protein composites using Capsicum annuum L extract (2007, background): “It has been confirmed that αSe can improve the activity of the seleno-enzyme, glutathione peroxidase, and prevent free radicals from damaging cells and tissues in vivo [12, 13].”
Antioxidant Activity and Total Phenolic Content of Moringa oleifera Leaves in Two Stages of Maturity (2009, methodology): “GPX activity was measured according to procedure where the [24] reaction mixture consisted of sodium phosphate buffer, pH 7.”
The antioxidant role of selenium and seleno-compounds. (2003, background): “It provides a second line of defense against hydroperoxides which can damage membranes and other cell structures [36].”
Homeostasis and toxicology of essential metals (2012, background): “History and Background Selenium was first recognized as an essential micronutrient in animals by the pioneering work of Schwarz and Foltz (1957), which was further supported by the discovery that Se was essential for glutathione peroxidase activity (Rotruck et al., 1973).”
An Overview of Selenium Uptake, Metabolism, and Toxicity in Plants (2017, background): “Another turning point in Se research came through the discovery of Se in enzyme Glutathione peroxidase (Rotruck et al., 1973; Behne and Kyriakopoulos, 2001).”
The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities (2012, background): “The first selenoprotein identified in mammals was GPX1 (cellular GPX) (208).”