CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

By J. Niess, S. Brand, Xiubin Gu, Limor Landsman, Steffen Jung, B. McCormick, J. Vyas, M. Boes, Hidde L. Ploegh, J. Fox and 2 more. Science, 2005

1,689 citations recorded by the source corpus.

Subfields: Endocrinology, Immunology

View Paper: https://www.semanticscholar.org/paper/715c0b3afa51fd7bff357448a202cd8a3b8a90ff

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. Y. Belkaid
2. O. Harrison
3. J. Turner
4. Bali Pulendran
5. L. Hooper
6. Eran Elinav
7. Shizuo Akira

In Immunology

1. Shizuo Akira
2. Y. Belkaid
3. Satoshi Uematsu
4. O. Harrison
5. K. Honda
6. R. Medzhitov
7. Steffen Jung
8. R. Ransohoff

Citations in the corpus

• Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells (2005, background): “The extension of the dendrites is regulated by expression of the fractalkine receptor (CX3CR1”
• International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “Human DCs are subdivided into CD104+ plasmacytoid DCs and conventional (or myeloid) CD11c+ DCs, the latter consisting of a CD16+ subset (;70%), a CD1c+ (also called BDCA-1 from blood dendritic cell antigen-1) subset (;30%), and a CD141+ (thrombomodulin, also called BDCA-3) subset (,5”
• Intestinal mucosal barrier function in health and disease (2009, background): “Although they may affect barrier function, dendritic cells (DCs), which extend dendritic processes across the tight junctions in the distal small intestin”
• Immune adaptations that maintain homeostasis with the intestinal microbiota (2010, background): “Lamina propria DCs also actively sample the small numbers of bacteria that are present at the apical surfaces of epithelial cells, allowing them to monitor bacteria that associate with the mucosal surfac”
• Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδT cells (2016, positive): “DC can directly sample intestinal content 29,30 and migrate to the mLN where they present antigens to induce T reg polarization 26 .”
• The Microbiome in Infectious Disease and Inflammation (2012, positive): “In addition, LP cells expressing CX3CR1 extend their cellular dendrites between the tight junctions of epithelial cells to take up luminal bacteria (158).”
• Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis (2012, positive): “…a GFP reporter in the CX 3 CR1 locus (Jung et al., 2000) have been instrumental in identifying and defining MDPs (Fogg et al., 2006), pre-DCs (Liu et al., 2009), as well as tissue-resident mononuclear phagocyte populations (Bar-On et al.; Lewis et al., 2011; Niess et al., 2005; Varol et al., 2009).”
• Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn’s disease (2008, background): “typhimurium strain SL1344 bearing a DsRed2 expression plasmid has been previously describe”
• Intestinal lamina propria dendritic cell subsets have different origin and functions. (2009, background): “…intestinal epithelium and send trans-epithelial dendrites (TEDs) toward the gut lumen to sense or sample luminal pathogens (Rescigno et al., 2001; Chieppa et al., 2006), and TEDs can be readily visualized in the lamina propria of Cx3cr1gfp/+ mice (Niess et al., 2005; Vallon- Eberhard et al., 2006).”
• Macrophages: development and tissue specialization. (2015, background): “These cells first gained major attention when they were visualized intravitally using Cx3cr1 reporter mice, which revealed their sheer abundance, strategic positioning in the lamina propria, and special access to the gut lumen (31, 96).”
• Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions (2009, methodology): “Given previous studies suggesting that CX3CR1+ cells capture luminal antigen for initiation of immune responses (Niess et al., 2005; Chieppa et al., 2006; Niess and Reinecker, 2006; Vallon-Eberhard et al., 2006; Hapfelmeier et al., 2008; Uematsu et al., 2008) and indirect evidence indicating that at”