Intestinal mucosal barrier function in health and disease

By J. Turner. Nature reviews. Immunology, 2009

3,618 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Surgery

View Paper: https://www.semanticscholar.org/paper/7032b5cfc31d0560d14b7bb7662b93a9d838a2e8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Neurology

In Surgery

Citations in the corpus

Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016, background): “Penetration of lipopolysaccharide into the bloodstream is controlled by the integrity of the gut barrier.48 Administration of A muciniphila has been shown to prevent the thinning of mucus layer in mice with diet-induced obesity.21 The mucus layer is enriched with various mucins that form a hydrated ”
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus (2011, background): “2131" language="eng" relation="no"> The maintenance of epithelial barrier function at mucosal sites such as the intestine and respiratory tract is critical for limiting exposure to environmental stimuli, commensal bacteria and invading pathogen”
Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases (2015, background): “org to be important in the initiation and/or development of several intestinal and systemic diseases.(1,10) In contrast, some growth factors play roles in protection and maintenance of TJ integrity.”
Tight Junction Pore and Leak Pathways: A Dynamic Duo (2011, background): “The clinical significance of intestinal barrier dysfunction has been the topic of numerous recent reviews and commentaries (14, 94, 113) and is not detailed here.”
Metagenomic biomarker discovery and explanation (2011, methodology): “from the Human Microbiome Project [55,56] assigning the main body sites to mucosal and non-mucosal classes, and using the body sites as”
Basics and recent advances in peptide and protein drug delivery (2013, positive): “Once a molecule passes the mucosal layer, however, the unstirred layer may act as an absorption enhancer by allowing the particle more time exposed to the epithelial barrier [21].”
Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4 (2014, positive): “…intestinal barrier function has been implicated in the pathogenesis of several disease states (e.g., type I diabetes, asthma, autism, acne, allergies etc.) including inflamatory bowel disease (IBD) (Gummesson et al., 2011; Islam and Luster, 2012; Mayer, 2011; Meier and Plevy, 2007; Turner, 2009).”
Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14. (2013, background): “An integral function of intestinal epithelial cells is to act as a physical barrier, separating the noxious luminal environment from the underlying lamina propria and the deeper intestinal layers.(1,2) The apically located tight junctions (TJs) form a paracellular seal between the lateral membranes ”
The intestinal barrier: a fundamental role in health and disease (2017, background): “The gastrointestinal (GI) tract harbors one of the largest luminal interaction areas of these barriers, and plays a pivotal role in the regulation of the immune system, and hence in health [1,2].”