Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study

By B. Vessby, M. Uusitupa, K. Hermansen, G. Riccardi, A. Rivellese, Linda C. Tapsell, C. Nälsén, L. Berglund, A. Louheranta, B. M. Rasmussen and 5 more. Diabetologia, 2001

1,161 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Physiology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/71273a99ac9aebb8524908888a3e368dfc2e2830

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Nutrition and Dietetics

1. F. B. Hu
2. W. Willett
3. U. Risérus
4. I. Graham
5. Qi Sun
6. D. Mozaffarian
7. F. B. Hu
8. M. Schulze

In Physiology

1. F. B. Hu
2. W. Willett
3. Jaspinder Kaur
4. Qi Sun
5. L. Thibault
6. I. Graham
7. N. Hariri
8. R. Eckel

In Public Health, Environmental and Occupational Health

1. F. B. Hu
2. W. Willett
3. Qi Sun
4. U. Risérus
5. I. Graham
6. Jaspinder Kaur
7. C. Apovian
8. D. Mozaffarian

Citations in the corpus

• The metabolic syndrome. (2008, background): “In general, the characteristics of this phenotype are more likely to include being overweight or obese (106, 110), being sedentary (108), and consuming a diet high in total or saturated fats (109).”
• High-fat diet-induced obesity in animal models (2010, background): “On the other hand, some studies have shown beneficial effects of MUFA intake on glucose homeostasis and insulin sensitivity((211)).”
• Saturated fat, carbohydrate, and cardiovascular disease. (2010, background): “37% of total energy; in contrast, in persons who consumed lower total fat intakes, saturated fat led to decreased insulin sensitivity compared with monounsaturated fat (116).”
• Dietary fats and prevention of type 2 diabetes (2008, methodology): “Animal experiments indicate that intake of fatty acids from the n-3 family, from fish oils in particular, have a beneficial effect on insulin sensitivity in rats [54], but not in healthy humans [12] or in subjects with type 2 diabetes as shown in several controlled studies [4,55].”
• Low-grade inflammation, diet composition and health: current research evidence and its translation (2015, neutral): “lack of impact of LC n-3 PUFA on the fasting plasma inflammasome in humans((66)) is in line with previous human studies((63,67)), but contradicts the effects observed in a wide”
• Nutrition Recommendations and Interventions for Diabetes (2008, background): “Of note, reduced intake of fat, particularly saturated fat, may reduce risk for diabetes by producing an energy-independent improvement in insulin resistance (1,33,34), as well as by promoting weight loss.”
• Rapeseed (Brassica napus): Processing, Utilization, and Genetic Improvement (2021, background): “Moreover, rich MUFA diets were reported to be suitable for diabetic subjects since they could improve glycemic control [67–70], blood lipids [71], and lower insulin response [72,73].”
• A Comprehensive Review on Metabolic Syndrome (2014, background): “Characteristics of the insulinsensitive phenotype include a normal body weight [77] without abdominal or visceral obesity [78], being moderately active [79], and consuming a diet low in saturated fats [80].”
• 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. (2016, background): “A high monounsaturated fat diet significantly improves insulin sensitivity compared with a high saturated fat diet.(170) This goes in parallel with a reduction in TG levels, mostly in the post-prandial period.”